Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tenofovir disoproxil
Drug ID BADD_D02155
Description Tenofovir disoproxil fumarate (a prodrug of tenofovir), marketed by Gilead Sciences under the trade name _Viread_, belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase inhibitors (nRTIs). This drug is prescribed in combination with other drugs for the management of HIV infection as well as for Hepatitis B therapy. Tenofovir disoproxil was initially approved in 2001 [FDA label].
Indications and Usage Tenofovir is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and pediatric patients 2 years of age and older. It is also indicated for the treatment of chronic hepatitis B in adults and pediatric patients 12 years of age and older.
Marketing Status Prescription
ATC Code J05AF07
DrugBank ID DB00300
KEGG ID D01982
MeSH ID D000068698
PubChem ID 5481350
TTD Drug ID D0D9HW
NDC Product Code 68554-0046
Synonyms Tenofovir | 9-(2-Phosphonylmethoxypropyl)adenine | 9-PMPA (tenofovir) | 9-(2-Phosphonomethoxypropyl)adenine | 9-(2-Phosphonylmethoxypropyl)adenine, (S)-isomer | 9-(2-Phosphonylmethoxypropyl)adenine, (+-)-isomer | Tenofovir Disoproxil Fumarate | Disoproxil Fumarate, Tenofovir | Fumarate, Tenofovir Disoproxil | Tenofovir Disoproxil | Disoproxil, Tenofovir | 9-(2-Phosphonylmethoxypropyl)adenine, (R)-isomer - T357098 | (R)-9-(2-phosphonylmethoxypropyl)adenine | Viread
Chemical Information
Molecular Formula C19H30N5O10P
CAS Registry Number 201341-05-1
SMILES CC(C)OC(=O)OCOP(=O)(COC(C)CN1C=NC2=C(N=CN=C21)N)OCOC(=O)OC(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Face oedema23.04.01.004; 10.01.05.002; 08.01.07.0030.013329%
Fanconi syndrome20.05.03.009; 14.01.01.011; 03.06.01.0010.022215%Not Available
Fatigue08.01.01.002--
Femoral neck fracture15.08.03.002; 12.04.01.0020.008886%Not Available
Femur fracture15.08.03.003; 12.04.01.003--Not Available
Flatulence07.01.04.002--
Foetal distress syndrome18.03.02.0030.013329%Not Available
Foot fracture15.08.03.012; 12.04.01.0120.035543%Not Available
Fracture15.08.02.001; 12.04.02.0010.088859%
Gait disturbance17.02.05.016; 08.01.02.002--
Gastric ulcer07.04.03.0020.013329%
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Gestational diabetes18.02.04.001; 14.06.01.008; 05.06.01.0080.013329%Not Available
Glomerular filtration rate decreased13.13.01.0090.031100%Not Available
Glycosuria20.02.01.005--
Guillain-Barre syndrome17.09.01.001; 11.07.01.001; 10.04.10.0050.008886%
Haematuria24.07.01.047; 20.02.01.006--
Blood urine present13.13.02.0020.008886%Not Available
Haemoglobin decreased13.01.05.003--Not Available
Hallucination19.10.02.002--
Headache17.14.01.001--
Heart disease congenital03.07.07.001; 02.01.01.0090.002318%Not Available
Heart rate increased13.14.04.002--Not Available
Hepatic cirrhosis09.01.04.0010.016226%Not Available
Hepatic encephalopathy17.13.01.003; 09.01.03.0060.002318%Not Available
Hepatic failure09.01.03.0020.017385%
Hepatic fibrosis24.08.06.002; 09.01.04.0020.013329%Not Available
Hepatic function abnormal09.01.02.0010.039986%Not Available
Hepatic necrosis09.01.07.0020.002318%
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