Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Temsirolimus
Drug ID BADD_D02151
Description Temsirolimus is a derivative of sirolimus used in the treatment of renal cell carcinoma (RCC). It was developed by Wyeth Pharmaceuticals under the trade name Torisel. Temsirolimus was approved by the FDA in late May 2007 as well as the European Medicines Agency (EMEA) on November 2007.
Indications and Usage For the treatment of renal cell carcinoma (RCC). Also investigated for use/treatment in breast cancer, lymphoma (unspecified), rheumatoid arthritis, and multiple myeloma.
Marketing Status Prescription
ATC Code L01EG01
DrugBank ID DB06287
KEGG ID D06068
MeSH ID C401859
PubChem ID 6918289
TTD Drug ID D0ES1Q
NDC Product Code 68254-6237; 0008-1179; 65219-200; 16729-223; 65727-047; 78848-002
Synonyms temsirolimus | rapamycin, 42-(3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate) | CCI 779 | CCI-779 | Torisel
Chemical Information
Molecular Formula C56H87NO16
CAS Registry Number 162635-04-3
SMILES CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O) C(C)CC4CCC(C(C4)OC)OC(=O)C(C)(CO)CO)C)C)O)OC)C)C)C)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abscess11.01.08.001--Not Available
Acne23.02.01.001--Not Available
Ageusia17.02.07.001; 07.14.03.003--Not Available
Alanine aminotransferase increased13.03.01.003--
Alveolitis22.01.01.001--Not Available
Alveolitis allergic22.01.01.002; 10.01.03.008--Not Available
Anaemia01.03.02.001--
Anal candidiasis23.09.02.014; 11.03.03.019; 07.19.04.006--Not Available
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Anxiety19.06.02.002--
Aphthous ulcer07.05.06.002--Not Available
Arthralgia15.01.02.001--
Aspartate aminotransferase increased13.03.01.006--
Asthenia08.01.01.001--Not Available
Back pain15.03.04.005--
Bladder pain20.02.02.001--Not Available
Blood bilirubin increased13.03.01.008--
Blood cholesterol increased13.12.01.002--
Blood creatinine increased13.13.01.004--
Blood glucose increased13.02.02.002--Not Available
Blood potassium decreased13.11.01.010--Not Available
Blood triglycerides increased13.12.03.001--Not Available
Body temperature increased13.15.01.001--Not Available
Bronchitis22.07.01.001; 11.01.09.001--
Cataract06.06.01.001--
Cellulitis11.02.01.001; 23.09.01.001--Not Available
Cervicobrachial syndrome17.10.02.001; 15.01.04.002--Not Available
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