Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Telmisartan
Drug ID BADD_D02147
Description Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. Generally, angiotensin II receptor blockers (ARBs) such as telmisartan bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle, ultimately leading to a reduction in arterial blood pressure. Recent studies suggest that telmisartan may also have PPAR-gamma agonistic properties that could potentially confer beneficial metabolic effects.
Indications and Usage Used alone or in combination with other classes of antihypertensives for the treatment of hypertension. Also used in the treatment of diabetic nephropathy in hypertensive patients with type 2 diabetes mellitus, as well as the treatment of congestive heart failure (only in patients who cannot tolerate ACE inhibitors).
Marketing Status approved; investigational
ATC Code C09CA07
DrugBank ID DB00966
KEGG ID D00627
MeSH ID D000077333
PubChem ID 65999
TTD Drug ID D0N6RF
NDC Product Code 72606-506; 10695-139; 65841-805; 68462-199; 68462-200; 72606-507; 55111-095; 62135-536; 62135-537; 62332-089; 65162-293; 71209-049; 52286-0024; 53104-7624; 65404-007; 42291-792; 42571-226; 62135-535; 62332-087; 0597-0041; 72241-017; 65841-804; 65862-868; 68071-2591; 72241-015; 72241-016; 65372-1146; 42291-790; 46708-608; 53002-1794; 71335-1428; 71335-2173; 12666-0010; 50370-0015; 64220-124; 65862-727; 68554-0049; 42571-227; 43547-284; 43547-285; 53746-291; 63629-5682; 0378-2920; 67877-482; 68382-472; 68382-473; 70518-3556; 0597-0039; 65404-006; 66039-895; 71052-679; 45865-836; 53746-292; 65841-806; 65862-867; 68071-5178; 71335-1723; 57451-1206; 46708-610; 67877-483; 68788-8440; 68788-8441; 70518-3300; 0597-0040; 62512-0040; 64552-4026; 65015-845; 42291-791; 43547-283; 53746-293; 62332-088; 0378-2921; 65862-869; 67877-484; 68462-201; 70518-2572; 71209-050; 71209-051; 72606-508; 52562-009; 72761-021; 42571-228; 46708-609; 50090-5490; 63187-951; 0378-2922; 65162-291; 65162-292; 68382-471; 71335-2191; 62331-032; 64220-171
UNII U5SYW473RQ
Synonyms Telmisartan | 4'-((1,4'-Dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl)methyl)-(1,1'-biphenyl)-2-carboxylic acid | Pritor | BIBR 277 | BIBR-277 | Micardis
Chemical Information
Molecular Formula C33H30N4O2
CAS Registry Number 144701-48-4
SMILES CCCC1=NC2=C(N1CC3=CC=C(C=C3)C4=CC=CC=C4C(=O)O)C=C(C=C2C)C5=NC6=CC=CC=C6N5C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hepatobiliary disease09.01.08.003--Not Available
Renal impairment20.01.03.0100.001952%Not Available
Unevaluable event08.01.03.0510.000911%Not Available
Muscle contracture15.03.05.0240.000390%Not Available
Cystitis noninfective20.03.02.001--
Chronic kidney disease20.01.03.0170.000521%
Tendon pain15.07.01.009--Not Available
Adverse reaction08.06.01.018--Not Available
Low birth weight baby18.04.02.0030.000521%Not Available
Oropharyngeal pain07.05.05.004; 22.12.03.0160.000260%
Acute kidney injury20.01.03.0160.003905%
Drug-induced liver injury12.03.01.044; 09.01.07.0230.001041%Not Available
Hepatic cancer16.07.02.004; 09.04.02.0080.000260%Not Available
Hepatocellular carcinoma16.07.02.005; 09.04.02.0100.000260%Not Available
Drug reaction with eosinophilia and systemic symptoms12.03.01.064; 23.03.05.005; 10.01.01.0210.000260%Not Available
Respiratory symptom22.12.02.0130.000390%Not Available
Nasal pruritus22.04.03.018--Not Available
Ureterolithiasis20.04.03.0030.000260%Not Available
Bronchial carcinoma16.19.02.004; 22.08.01.0150.000260%Not Available
IgA nephropathy20.05.01.016; 10.02.01.0630.000911%Not Available
Neonatal respiratory distress syndrome22.11.02.010; 18.04.10.0030.000260%Not Available
Neonatal respiratory failure22.11.02.011; 18.04.17.0030.000651%Not Available
Primary hyperaldosteronism14.05.04.010; 05.01.01.007; 24.08.04.0060.000260%Not Available
Renal failure neonatal20.01.03.024; 18.04.01.0190.000260%Not Available
Neonatal hypotension24.06.03.014; 18.04.07.0080.000651%Not Available
Live birth18.08.02.0070.000390%Not Available
Small intestinal haemorrhage24.07.02.019; 07.12.03.0020.000260%
Eosinophilic colitis07.08.01.019; 01.02.04.0150.000521%Not Available
Gastrointestinal oedema07.11.01.0120.000260%Not Available
Cranial sutures widening18.04.01.015; 15.10.05.0020.000390%Not Available
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