| Pharmaceutical Information |
| Drug Name |
Telmisartan |
| Drug ID |
BADD_D02147 |
| Description |
Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. Generally, angiotensin II receptor blockers (ARBs) such as telmisartan bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle, ultimately leading to a reduction in arterial blood pressure. Recent studies suggest that telmisartan may also have PPAR-gamma agonistic properties that could potentially confer beneficial metabolic effects. |
| Indications and Usage |
Used alone or in combination with other classes of antihypertensives for the treatment of hypertension. Also used in the treatment of diabetic nephropathy in hypertensive patients with type 2 diabetes mellitus, as well as the treatment of congestive heart failure (only in patients who cannot tolerate ACE inhibitors). |
| Marketing Status |
Prescription |
| ATC Code |
C09CA07 |
| DrugBank ID |
DB00966
|
| KEGG ID |
D00627
|
| MeSH ID |
D000077333
|
| PubChem ID |
65999
|
| TTD Drug ID |
D0N6RF
|
| NDC Product Code |
68554-0049; 43547-283; 67877-484; 65862-868; 71335-0875; 65162-292; 72241-015; 65404-007; 62512-0040; 53104-7624; 65862-867; 46708-610; 71335-1723; 62332-088; 42571-226; 0378-2921; 62332-089; 62332-087; 65162-291; 65372-1146; 71209-049; 52562-009; 68462-199; 65162-293; 53746-291; 43547-284; 55545-0701; 72241-016; 0781-5374; 45865-836; 0597-0041; 70518-2572; 31722-803; 71335-1841; 13668-156; 42571-228; 57451-1206; 0781-5378; 53746-292; 12666-0010; 68071-2591; 50090-5489; 71052-679; 63629-5682; 43547-285; 62331-032; 67877-483; 71335-1428; 55111-095; 0378-2922; 71209-051; 72761-021; 72606-507; 50090-5490; 31722-804; 50370-0015; 67877-482; 68382-471; 52286-0024; 50090-5492; 68071-4937; 68382-473; 65862-869; 68462-200; 64552-4026; 31722-802; 65862-727; 68462-201; 0597-0039; 0378-2920; 65841-806; 68071-5178; 72606-506; 46708-864; 42291-792; 42291-791; 72969-100; 53746-293; 65841-805; 70518-3300; 13668-158; 65015-845; 13668-157; 63187-951; 68382-472; 46708-609; 64220-124; 72241-017; 71209-050; 42291-790; 0781-5372; 42571-227; 65841-804; 46708-608; 63629-7230; 17511-126; 72606-508; 0597-0040; 66039-895 |
| Synonyms |
Telmisartan | 4'-((1,4'-Dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl)methyl)-(1,1'-biphenyl)-2-carboxylic acid | Pritor | BIBR 277 | BIBR-277 | Micardis |
|
| Chemical Information |
| Molecular Formula |
C33H30N4O2 |
| CAS Registry Number |
144701-48-4 |
| SMILES |
CCCC1=NC2=C(N1CC3=CC=C(C=C3)C4=CC=CC=C4C(=O)O)C=C(C=C2C)C5=NC6=CC=CC=C6N5C |
| Chemical Structure |
|
|
| ADR Related Proteins Induced by Drug |
| ADR Term |
Protein Name |
UniProt AC |
TTD Target ID |
PMID |
| Not Available | Not Available | Not Available | Not Available | Not Available |
|
| ADRs Induced by Drug |
|
| ADR Term |
ADReCS ID |
ADR Frequency (FAERS)
|
ADR Severity Grade (FAERS)
|
ADR Severity Grade (CTCAE)
|
| Prerenal failure | 20.01.03.022; 24.06.02.025 | 0.001280% | | Not Available |
|
|
|
