Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tapentadol
Drug ID BADD_D02115
Description Opioid analgesic for treatment of moderate to severe pain. FDA approved on Nov 20, 2008.
Indications and Usage The immediate-release formulation of tapentadol is indicated for the relief of moderate to severe acute pain. The long-acting formulation serves as a continuous, around-the-clock analgesic that is indicated for the relief of moderate to severe chronic pain or neuropathic pain associated with diabetic peripheral neuropathy.
Marketing Status Prescription
ATC Code N02AX06
DrugBank ID DB06204
KEGG ID D06007
MeSH ID D000077432
PubChem ID 9838022
TTD Drug ID D0K4MH
NDC Product Code Not Available
Synonyms Tapentadol | 3-((1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl)phenol | Nucynta | Tapentadol Hydrochloride
Chemical Information
Molecular Formula C14H23NO
CAS Registry Number 175591-23-8
SMILES CCC(C1=CC(=CC=C1)O)C(C)CN(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Migraine24.03.05.003; 17.14.02.0010.008760%Not Available
Miosis06.05.03.003; 17.02.11.0020.018979%Not Available
Mood altered19.04.02.0070.002920%Not Available
Mood swings19.04.03.0010.004380%Not Available
Muscle spasms15.05.03.004--
Muscle twitching15.05.03.0050.004380%Not Available
Mydriasis17.02.11.003; 06.05.03.0040.002920%Not Available
Myoclonus17.02.05.0080.002920%Not Available
Nausea07.01.07.0010.064238%
Neck pain15.03.04.0090.002920%
Neoplasm malignant16.16.01.001--Not Available
Nervousness19.06.02.0030.011680%Not Available
Neuralgia17.02.07.0050.002920%
Neuropathy peripheral17.09.03.003--Not Available
Neutropenia01.02.03.004--Not Available
Nightmare19.02.03.0030.005840%Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Oxygen saturation decreased13.02.01.0040.005840%Not Available
Pain08.01.08.0040.045258%
Pain in extremity15.03.04.010--
Pallor08.01.03.032; 24.03.04.001; 23.03.03.0310.002920%Not Available
Palpitations02.01.02.0030.018979%
Pancreatitis07.18.01.0010.007300%
Panic attack19.06.04.0010.007300%Not Available
Paraesthesia17.02.06.005--
Pneumonia11.01.09.003; 22.07.01.003--Not Available
Presyncope17.02.05.009; 02.01.02.007; 24.06.02.0100.002920%
Pruritus23.03.12.0010.030659%
Psychomotor hyperactivity19.11.02.003; 17.01.02.0110.005840%Not Available
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