Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tapentadol
Drug ID BADD_D02115
Description Opioid analgesic for treatment of moderate to severe pain. FDA approved on Nov 20, 2008.
Indications and Usage The immediate-release formulation of tapentadol is indicated for the relief of moderate to severe acute pain. The long-acting formulation serves as a continuous, around-the-clock analgesic that is indicated for the relief of moderate to severe chronic pain or neuropathic pain associated with diabetic peripheral neuropathy.
Marketing Status Prescription
ATC Code N02AX06
DrugBank ID DB06204
KEGG ID D06007
MeSH ID D000077432
PubChem ID 9838022
TTD Drug ID D0K4MH
NDC Product Code Not Available
Synonyms Tapentadol | 3-((1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl)phenol | Nucynta | Tapentadol Hydrochloride
Chemical Information
Molecular Formula C14H23NO
CAS Registry Number 175591-23-8
SMILES CCC(C1=CC(=CC=C1)O)C(C)CN(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Drug withdrawal syndrome08.06.02.004; 19.07.02.0110.020439%Not Available
Dry mouth07.06.01.0020.005840%
Dysaesthesia17.02.06.0030.002920%
Dysarthria19.19.03.001; 17.02.08.0010.008760%
Dyskinesia17.01.02.0060.002920%
Dyspepsia07.01.02.0010.004380%
Dysphagia07.01.06.0030.020439%
Dysphonia22.02.05.005; 19.19.03.002; 17.02.08.0040.002920%
Dyspnoea02.01.03.002; 22.02.01.004--
Dysuria20.02.02.0020.005840%
Emotional disorder19.04.02.0050.002920%Not Available
Epilepsy17.12.03.0020.002920%Not Available
Erythema23.03.06.001--Not Available
Euphoric mood19.04.02.0060.008760%
Fatigue08.01.01.002--
Fear19.06.03.0010.002920%Not Available
Feeling abnormal08.01.09.0140.023359%Not Available
Feeling cold08.01.09.0080.002920%Not Available
Feeling drunk08.01.09.0150.004380%Not Available
Feeling jittery08.01.09.0160.008760%Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.0250.004380%
Gait disturbance17.02.05.016; 08.01.02.002--
Gamma-glutamyltransferase increased13.03.01.0110.004380%
Gastrooesophageal reflux disease07.02.02.0030.004380%
Gastrointestinal disorder07.11.01.001--Not Available
Generalised anxiety disorder19.06.01.0040.002920%Not Available
Generalised tonic-clonic seizure17.12.01.0020.004380%Not Available
Haematochezia24.07.02.012; 07.12.02.0030.005840%Not Available
Hallucination19.10.02.0020.043798%
Hallucination, auditory19.10.02.0030.005840%Not Available
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