Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tapentadol
Drug ID BADD_D02115
Description Opioid analgesic for treatment of moderate to severe pain. FDA approved on Nov 20, 2008.
Indications and Usage The immediate-release formulation of tapentadol is indicated for the relief of moderate to severe acute pain. The long-acting formulation serves as a continuous, around-the-clock analgesic that is indicated for the relief of moderate to severe chronic pain or neuropathic pain associated with diabetic peripheral neuropathy.
Marketing Status Prescription
ATC Code N02AX06
DrugBank ID DB06204
KEGG ID D06007
MeSH ID D000077432
PubChem ID 9838022
TTD Drug ID D0K4MH
NDC Product Code Not Available
Synonyms Tapentadol | 3-((1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl)phenol | Nucynta | Tapentadol Hydrochloride
Chemical Information
Molecular Formula C14H23NO
CAS Registry Number 175591-23-8
SMILES CCC(C1=CC(=CC=C1)O)C(C)CN(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Body temperature increased13.15.01.0010.002920%Not Available
Bradycardia02.03.02.0020.008760%Not Available
Cardiac arrest02.03.04.001--
Cardio-respiratory arrest22.02.06.007; 02.03.04.0020.001143%Not Available
Cerebrovascular accident17.08.01.007; 24.03.05.001--
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chills15.05.03.016; 08.01.09.001--
Chromaturia20.02.01.0020.002920%
Chronic obstructive pulmonary disease22.03.01.0070.001143%Not Available
Coma17.02.09.0010.008760%Not Available
Completed suicide19.12.01.001; 08.04.01.010--Not Available
Confusional state17.02.03.005; 19.13.01.0010.039419%
Constipation07.02.02.0010.027739%
Coordination abnormal17.02.02.0040.002920%Not Available
Cough22.02.03.001--
Crying19.04.02.002; 17.02.05.013; 12.02.11.001; 08.01.03.0050.005840%Not Available
Death08.04.01.001--
Delirium19.13.02.0010.037959%
Delusion19.10.01.0010.013140%
Depressed level of consciousness17.02.04.0020.011680%
Depressed mood19.15.02.0010.004380%Not Available
Depression19.15.01.001--
Diarrhoea07.02.01.001--
Diplegia17.01.04.0150.002920%Not Available
Disorientation17.02.05.015; 19.13.01.0020.007300%Not Available
Disturbance in attention19.21.02.002; 17.03.03.0010.002920%
Dizziness02.01.02.004; 24.06.02.007; 17.02.05.0030.049638%
Drug abuse19.07.02.0100.006855%Not Available
Drug dependence19.07.02.0090.010220%Not Available
Drug hypersensitivity10.01.01.001--Not Available
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