Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tamoxifen
Drug ID BADD_D02111
Description Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment for these types of cancers as patients generally have better survival, side effect profiles, and compliance with [anastrozole].[A1026] Tamoxifen was granted FDA approval on 30 December 1977.[L7799]
Indications and Usage Tamoxifen is indicated for the treatment of metastatic breast cancer in women and men and ductal carcinoma in Situ.
Marketing Status Prescription; Discontinued
ATC Code L02BA01
DrugBank ID DB00675
KEGG ID D08559
MeSH ID D013629
PubChem ID 2733526
TTD Drug ID D07KSG
NDC Product Code Not Available
Synonyms Tamoxifen | ICI-47699 | ICI 47699 | ICI47699 | Nolvadex | Novaldex | Tamoxifen Citrate | Citrate, Tamoxifen | Tomaxithen | Zitazonium | ICI-46474 | ICI 46474 | ICI46474 | ICI-46,474 | ICI 46,474 | ICI46,474 | Soltamox
Chemical Information
Molecular Formula C26H29NO
CAS Registry Number 10540-29-1
SMILES CCC(=C(C1=CC=CC=C1)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Tumour flare16.32.03.001--Not Available
Tumour pain16.32.03.003--
Uterine cancer21.07.02.003; 16.12.05.0010.002047%Not Available
Uterine leiomyoma21.07.02.004; 16.04.02.001--Not Available
Vaginal discharge21.08.02.002--
Vaginal haemorrhage24.07.03.005; 21.08.01.001--
Vertigo17.02.12.002; 04.04.01.0030.001024%
Visual acuity reduced17.17.01.011; 06.02.03.0010.001024%
Vomiting07.01.07.003--
Weight increased13.15.01.0060.003071%
Malignant neoplasm progression16.16.01.0050.000267%Not Available
Musculoskeletal stiffness15.03.01.0050.001535%Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Cutaneous lupus erythematosus23.03.02.008; 15.06.02.007; 10.04.03.007--Not Available
Vulvovaginal pruritus23.03.12.009; 21.08.02.004--Not Available
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.0270.002559%
Ocular toxicity12.03.01.031; 06.11.01.0060.002047%Not Available
Genital haemorrhage24.07.03.007; 21.10.05.0020.001024%Not Available
Optic nerve disorder17.04.05.004; 06.02.08.001--
Polyp08.01.06.010; 16.02.02.005--Not Available
Liver injury12.01.02.003; 09.01.07.022--Not Available
Bladder transitional cell carcinoma20.03.04.003; 16.08.01.0020.001024%Not Available
Metastases to bone16.22.02.005; 15.09.03.0060.001024%Not Available
Quality of life decreased13.18.01.0130.001535%Not Available
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