Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Sumatriptan succinate
Drug ID BADD_D02099
Description Sumatriptan is a serotonin receptor agonist commonly used to treat migraines and sometimes cluster headaches.[L6793,L6796,L6799,L6805,L6808,L6811] Sumatriptan is the first of the triptans and was made available in Europe in 1991 to treat migraines.[A179761] Sumatriptan was granted FDA approval on 28 December 1992.[L6805]
Indications and Usage A combination sumatriptan and [naproxen] tablet is indicated for the treatment of migraines with or without auras in patients 12 years of age and older.[L6793] Sumatriptan nasal powder, nasal spray, subcutaneous injection, and tablets are indicated to treat migraines with or without auras in adults.[L6796,L6799,L6805,L6808,L6811] One of the subcutaneous formulations of sumatriptan is also indicated to treat cluster headaches in adults[L6805], while the other subcutaneous formulation is not.[L6808]
Marketing Status approved; investigational
ATC Code N02CC01
DrugBank ID DB00669
KEGG ID D00676
MeSH ID D018170
PubChem ID 59772
TTD Drug ID D0Z6UC
NDC Product Code 52932-0727; 62331-049; 65862-146; 65862-148; 50090-1130; 53002-1592; 55111-693; 0378-5631; 72189-432; 0093-2014; 49574-517; 53104-7581; 53002-2592; 62756-522; 50370-0014; 51552-1376; 55111-060; 65015-860; 65015-864; 16714-796; 43598-768; 51407-011; 51407-013; 62756-520; 63187-931; 68071-2283; 60429-994; 62756-521; 63187-607; 71205-111; 49452-7585; 65862-147; 51407-012; 53002-1562; 53002-2593; 55700-759; 55700-899; 63187-049; 63187-617; 0378-5630; 76420-499; 35356-439; 42847-311; 55111-293; 63187-797; 68788-6778; 70518-1184; 0378-5632; 62756-730; 16714-797; 47335-276; 0245-0809; 55111-291; 55111-292; 63187-969; 68788-9547; 70594-068; 76420-093; 53069-0560; 57315-216; 67835-5010; 16714-798; 50090-2144; 70518-1183; 71205-251; 71205-725; 76420-498; 76420-500; 59651-151; 71205-274; 72189-433; 72603-141; 0093-2013; 65862-371; 50090-1129; 50090-5939; 53002-1593; 53002-2562; 63323-273; 68788-6769; 68788-8205; 70518-2859; 48087-0075; 57315-214; 57315-215; 16714-040; 45865-570; 55700-936
UNII J8BDZ68989
Synonyms Sumatriptan | 3-(2-(Dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide | Sumatriptan Succinate | Succinate, Sumatriptan | GR-43175 | GR 43175 | GR43175 | Imigran
Chemical Information
Molecular Formula C18H27N3O6S
CAS Registry Number 103628-48-4
SMILES CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C.C(CC(=O)O)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Prinzmetal angina24.04.04.015; 02.02.02.019--Not Available
Pruritus23.03.12.001--
Pulmonary embolism24.01.06.001; 22.06.02.001--Not Available
Pulse abnormal13.14.04.004--Not Available
Pyrexia08.05.02.003--
Radiculopathy17.10.01.005--
Rash23.03.13.001--Not Available
Raynaud's phenomenon24.04.03.003--Not Available
Rectal haemorrhage24.07.02.018; 07.12.03.001--
Respiratory disorder22.02.07.002--Not Available
Retching07.01.07.002--Not Available
Retinal artery occlusion24.01.07.003; 06.10.01.005--Not Available
Retinal vein thrombosis06.10.01.003; 24.01.07.002--Not Available
Rheumatoid arthritis15.01.03.001; 10.04.06.001--Not Available
Rhinitis allergic22.04.04.003; 10.01.04.003--
Salivary gland enlargement07.06.03.002--Not Available
Salivary hypersecretion07.06.01.009--Not Available
Seborrhoeic dermatitis23.03.04.018--Not Available
Sedation17.02.04.005--Not Available
Seizure17.12.03.001--
Sensory disturbance17.02.07.006--Not Available
Serotonin syndrome17.05.02.004; 15.05.04.016; 12.03.01.041--Not Available
Shock24.06.02.002--Not Available
Sinusitis22.07.03.007; 11.01.13.005--
Skin exfoliation23.03.07.003--Not Available
Skin wrinkling23.01.03.001--Not Available
Sleep disorder19.02.04.001--Not Available
Speech disorder22.12.03.027; 19.19.02.002; 17.02.08.003--Not Available
Stress19.06.02.004--Not Available
Subarachnoid haemorrhage24.07.04.004; 17.08.01.010; 12.01.10.011--Not Available
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