Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Sulfasalazine
Drug ID BADD_D02093
Description A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see mesalamine) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
Indications and Usage For the treatment of Crohn's disease and rheumatoid arthritis as a second-line agent.
Marketing Status approved
ATC Code A07EC01
DrugBank ID DB00795
KEGG ID D00448
MeSH ID D012460
PubChem ID 5339
TTD Drug ID D02ZTJ
NDC Product Code 63629-5688; 49452-7523; 59116-0631; 0093-3234; 70518-0185; 51552-1044; 51927-0081; 50090-2013; 59762-5000; 62135-960; 70518-1829; 70518-3732; 0013-0102; 71610-577; 62705-0222; 62991-2704; 59762-0104; 70518-2342; 71610-706; 49964-0018; 57294-021; 50090-0086; 51927-0054; 59116-0632; 0591-0796; 23155-019; 0013-0101; 63629-9715; 38779-0176; 59116-0630; 59116-0633; 68022-7065
UNII 3XC8GUZ6CB
Synonyms Sulfasalazine | Salicylazosulfapyridine | Sulphasalazine | Salazosulfapyridine | Pyralin EN | Azulfadine | Azulfidine EN | Azulfidine | Asulfidine | Colo-Pleon | Colo Pleon | Pleon | Ulcol | Sulfasalazin medac | Sulfasalazin-Heyl | Sulfasalazin Heyl | Sulfasalazine FNA | Ucine | Salazopyrin | ratio-Sulfasalazine | ratio Sulfasalazine
Chemical Information
Molecular Formula C18H14N4O5S
CAS Registry Number 599-79-1
SMILES C1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N=NC3=CC(=C(C=C3)O)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Oligospermia21.03.03.005--
Oliguria20.01.03.004--Not Available
Oral mucosal blistering07.05.05.0170.000667%Not Available
Oral pain07.05.05.0340.000303%
Osteoarthritis15.01.04.0010.000909%Not Available
Painful respiration22.12.02.011--Not Available
Pallor24.03.04.001; 23.03.03.031; 08.01.03.032--Not Available
Pancreatitis07.18.01.001--
Pancytopenia01.03.03.0030.002122%Not Available
Paranoia19.05.01.005--Not Available
Pemphigoid23.03.01.004; 10.04.02.0020.000455%Not Available
Pericardial effusion02.06.01.0020.000758%
Pericarditis02.06.02.001--
Periorbital oedema23.04.01.002; 10.01.05.010; 06.08.03.017--
Peripheral coldness24.04.03.006; 08.01.09.010; 23.06.04.008--Not Available
Petechiae24.07.06.004; 23.06.01.003; 01.01.03.002--Not Available
Photophobia17.17.02.006; 06.01.01.0040.000455%
Photosensitivity reaction23.03.09.0030.001697%
Pleural effusion22.05.02.0020.001970%
Pleurisy22.05.01.0010.000455%Not Available
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Pneumonitis22.01.01.0060.000758%
Polyarteritis nodosa15.06.01.003; 10.02.02.001; 24.12.04.019; 20.01.02.004--Not Available
Polyarthritis15.01.01.0050.000455%Not Available
Polyneuropathy17.09.03.0120.000303%Not Available
Polyuria20.02.03.002--Not Available
Pregnancy18.08.02.004--Not Available
Premature baby18.04.02.001--Not Available
Productive cough22.02.03.0050.000818%
Proteinuria20.02.01.011--
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ADReCS-Target
Drug Name ADR Term Target
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