Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sulfasalazine
Drug ID BADD_D02093
Description A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see mesalamine) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
Indications and Usage For the treatment of Crohn's disease and rheumatoid arthritis as a second-line agent.
Marketing Status Prescription; Discontinued
ATC Code A07EC01
DrugBank ID DB00795
KEGG ID D00448
MeSH ID D012460
PubChem ID 5339
TTD Drug ID D02ZTJ
NDC Product Code 68071-4215; 23155-019; 70518-1829; 50090-0086; 49964-0018; 43353-495; 63629-5688; 70518-0185; 51927-0054; 51927-0081; 0591-0796; 0013-0101; 59762-0104; 38779-0176; 0013-0102; 50268-730; 59116-0632; 62705-0222; 62991-2704; 57294-021; 59116-0631; 71610-577; 59762-5000; 59116-0633; 59116-0630; 62135-960; 51552-1044; 50090-2013; 49452-7523; 68022-7065; 70518-2342
Synonyms Sulfasalazine | Salicylazosulfapyridine | Sulphasalazine | Salazosulfapyridine | Pyralin EN | Azulfadine | Azulfidine EN | Azulfidine | Asulfidine | Colo-Pleon | Colo Pleon | Pleon | Ulcol | Sulfasalazin medac | Sulfasalazin-Heyl | Sulfasalazin Heyl | Sulfasalazine FNA | Ucine | Salazopyrin | ratio-Sulfasalazine | ratio Sulfasalazine
Chemical Information
Molecular Formula C18H14N4O5S
CAS Registry Number 599-79-1
SMILES C1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N=NC3=CC(=C(C=C3)O)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Leukopenias NECCytochrome P450 1A2P05177Not Available11600468; 11856081; 11600469
VasculitisMyeloperoxidaseP05164T234717913504; 7913503; 8102951; 7914458; 8624621; 7869327; 7835022; 8095074; 8624617
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chills08.01.09.001; 15.05.03.0160.005526%
Choking22.02.05.0010.002072%Not Available
Cholestasis09.01.01.001--Not Available
Chromaturia20.02.01.002--
Cirrhosis alcoholic09.01.04.005--Not Available
Clostridium difficile colitis11.02.02.004; 07.19.01.0040.001382%Not Available
Coagulopathy01.01.02.0010.001382%Not Available
Cold sweat23.02.03.002; 08.01.03.0240.001382%Not Available
Colitis07.08.01.0010.005526%
Colitis ulcerative10.02.01.004; 07.08.01.0050.008980%Not Available
Colon cancer16.13.01.001; 07.21.01.0010.000721%Not Available
Coma17.02.09.001--Not Available
Completed suicide08.04.01.010; 19.12.01.001--Not Available
Constipation07.02.02.001--
Cough22.02.03.001--
Crohn's disease10.02.01.005; 07.08.01.0150.002072%Not Available
Crystalluria20.02.01.003--Not Available
Cyanosis24.03.01.007; 22.02.02.007; 02.01.02.002--
Cytomegalovirus infection11.05.01.0020.004835%
Deafness04.02.01.001--Not Available
Death08.04.01.001--
Dehydration14.05.05.001--
Dementia19.20.02.001; 17.03.01.0010.002072%Not Available
Demyelination17.16.02.0010.001382%Not Available
Depression19.15.01.001--
Dermatitis23.03.04.0020.001382%Not Available
Dermatitis allergic23.03.04.003; 10.01.03.0140.001382%Not Available
Dermatitis exfoliative23.03.07.001; 10.01.01.004--
The 3th Page    First    Pre   3 4 5 6 7    Next   Last    Total 15 Pages