Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sodium bicarbonate
Drug ID BADD_D02034
Description Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.
Indications and Usage Sodium bicarbonate is used for the treatment of metabolic acidosis which may occur in severe renal disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal circulation of blood, cardiac arrest and severe primary lactic acidosis. Also is indicated in severe diarrhea which is often accompanied by a significant loss of bicarbonate. Further indicated in the treatment of certain drug intoxications, including barbiturates (where dissociation of the barbiturateprotein complex is desired), in poisoning by salicylates or methyl alcohol and in hemolytic reactions requiring alkalinization of the urine to diminish nephrotoxicity of blood pigments.
Marketing Status Prescription; Discontinued
ATC Code B05CB04; B05XA02
DrugBank ID DB01390
KEGG ID D01203
MeSH ID D017693
PubChem ID 516892
TTD Drug ID D02FLB
NDC Product Code 63323-089; 51754-5012; 0536-1046; 55154-6754; 50090-0530; 64980-294; 76328-221; 76328-223; 51552-0059; 52584-916; 69276-200; 24286-1523; 69618-035; 52584-900; 76329-3352; 63323-083; 71872-7111; 51662-1497; 54738-020; 70491-102; 70369-001; 0395-9124; 44224-1750; 43353-162; 63629-8775; 71872-7098; 10237-591; 10135-685; 51754-5011; 0409-5534; 0409-6625; 52584-534; 64980-528; 10135-684; 0404-9949; 53145-300; 0404-9980; 10237-590; 71610-438; 0404-9951; 43353-041; 70491-105; 0409-4916; 80760-201; 70795-1130; 71872-7266; 0395-2685; 72572-740; 81647-140; 71610-445; 51754-5002; 44224-3622; 51662-1573; 52584-099; 51662-1383; 71872-7097; 0536-1047; 0409-6637; 52584-096; 90107-1103; 49452-6610; 51754-5001; 54738-035; 52682-206; 51662-1255; 70369-002; 71901-604; 10106-3510; 70795-1180; 70795-1190; 69618-034; 10106-3509; 58989-001; 57896-676; 0409-4900; 0404-9948; 10095-100; 90107-1030; 51662-1400; 0409-5555; 71872-7247; 24286-1537; 0802-2685
Synonyms Sodium Bicarbonate | Bicarbonate, Sodium | Carbonic Acid Monosodium Salt | Sodium Hydrogen Carbonate | Hydrogen Carbonate, Sodium | Baking Soda | Soda, Baking
Chemical Information
Molecular Formula NaHCO3
CAS Registry Number 144-55-8
SMILES C(=O)(O)[O-].[Na+]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.0020.002047%
Blood creatine phosphokinase increased13.04.01.0010.002047%
Bradycardia02.03.02.0020.002047%Not Available
Bronchospasm22.03.01.004; 10.01.03.0120.002047%
Cardiac arrest02.03.04.0010.000534%
Cellulitis23.09.01.001; 11.02.01.001--Not Available
Chills15.05.03.016; 08.01.09.0010.002047%
Death08.04.01.001--
Dizziness17.02.05.003; 02.01.02.004; 24.06.02.0070.002047%
Drug abuse19.07.02.0100.000534%Not Available
Dysgeusia17.02.07.003; 07.14.03.0010.002047%
Dyspnoea22.02.01.004; 02.01.03.0020.002047%
Encephalopathy17.13.02.0010.011258%
Headache17.14.01.001--
Hypernatraemia14.05.04.001--
Hypokalaemia14.05.03.0020.002047%
Hypotension24.06.03.0020.000534%
Infection11.01.08.0020.000801%Not Available
Laceration23.03.11.004; 12.01.06.0060.023540%Not Available
Malaise08.01.01.0030.003070%
Metabolic acidosis14.01.01.0030.004094%Not Available
Metabolic alkalosis14.01.02.004--Not Available
Myalgia15.05.02.0010.004094%
Nausea07.01.07.001--
Necrosis24.04.02.006; 08.03.03.001--Not Available
Pain08.01.08.0040.002047%
Pyrexia08.05.02.0030.004094%
Respiratory depression17.02.05.047; 22.02.01.0100.000534%Not Available
Respiratory failure22.02.06.002; 14.01.04.0030.000534%
Rhabdomyolysis15.05.05.0020.002047%
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