Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sevelamer
Drug ID BADD_D02012
Description Sevelamer is a phosphate binding drug used to prevent hyperphosphataemia in patients with chronic renal failure. It is marketed by Genzyme under the trade name Renagel.
Indications and Usage For the control of serum phosphorus in patients with Chronic Kidney Disease (CKD) on hemodialysis.
Marketing Status Prescription; Discontinued
ATC Code V03AE02
DrugBank ID DB00658
KEGG ID D08512
MeSH ID D000069603
PubChem ID 3085017
TTD Drug ID D03MZQ
NDC Product Code Not Available
Synonyms Sevelamer | GT335-012 | GT335 012 | GT335012 | Sevelamer Hydrochloride | Hydrochloride, Sevelamer | RenaGel | Sevelamer Carbonate | Carbonate, Sevelamer
Chemical Information
Molecular Formula C6H12ClNO
CAS Registry Number 52757-95-6
SMILES C=CCN.C1C(O1)CCl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gastritis07.08.02.0010.003950%
Gastrooesophageal reflux disease07.02.02.003--
Gastroenteritis11.01.07.004; 07.19.03.0010.002962%Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Gastrointestinal pain07.01.05.005--
Haematochezia24.07.02.012; 07.12.02.0030.018761%Not Available
Haemorrhoids24.10.02.002; 07.15.03.001--
Hallucination19.10.02.002--
Headache17.14.01.001--
Hepatocellular injury09.01.07.008--Not Available
Hyperphosphataemia14.04.03.0070.046410%
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypoaesthesia17.02.06.023--Not Available
Hypotension24.06.03.002--
Ileus07.13.01.001--
Intermittent claudication24.04.03.0010.002962%Not Available
Intestinal obstruction07.13.01.0020.044435%Not Available
Intestinal perforation07.04.06.0020.001288%Not Available
Irritable bowel syndrome19.24.01.003; 07.02.04.0030.001975%Not Available
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.004--Not Available
Joint stiffness15.01.02.003--Not Available
Laboratory test abnormal13.18.01.001--Not Available
Large intestinal ulcer07.04.06.0040.002962%
Large intestine perforation12.02.03.005; 07.04.06.0050.001288%
Malaise08.01.01.003--
Melaena07.12.02.004; 24.07.02.013--Not Available
Mucosal inflammation08.01.06.002--Not Available
Mucosal ulceration08.01.06.0030.001975%Not Available
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