Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sertraline hydrochloride
Drug ID BADD_D02011
Description Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Indications and Usage It may be used for premature ejaculation and vascular headaches as off-label indications.
Marketing Status Prescription; Discontinued
ATC Code N06AB06
DrugBank ID DB01104
KEGG ID D00825
MeSH ID D020280
PubChem ID 63009
TTD Drug ID D0K0TC
NDC Product Code 16714-612; 55700-340; 43602-979; 53869-4900; 0049-4960; 68071-4029; 71093-129; 65841-044; 65841-043; 50090-2080; 72865-205; 45865-518; 59762-0067; 71205-343; 65015-821; 43602-980; 61919-345; 46144-108; 55700-910; 68071-3071; 53002-3192; 70518-0094; 0049-4900; 65862-013; 70518-1350; 63187-859; 72789-088; 68071-4658; 65977-0056; 68071-3146; 64980-409; 61919-014; 43353-970; 53002-1507; 50090-3203; 68071-4993; 68788-8109; 71205-028; 31722-147; 43063-855; 65841-045; 51655-265; 68071-1911; 60760-737; 71205-455; 71205-205; 68071-4973; 53104-7590; 50436-0217; 53808-1127; 65862-222; 50090-2976; 50436-0216; 16729-216; 60687-242; 53002-1192; 70518-3145; 43353-447; 68071-2496; 67046-559; 55700-948; 65862-011; 60760-738; 51655-345; 71610-433; 68788-6429; 68788-7928; 72189-122; 60687-253; 65862-012; 61919-086; 42708-124; 71610-106; 53002-4215; 43063-033; 71093-143; 51655-173; 63629-8774; 63629-8127; 70934-192; 71335-0328; 60760-091; 69097-833; 71335-0210; 65977-0002; 53002-3215; 65862-224; 68071-4462; 55700-362; 71335-0415; 72865-206; 68071-3309; 55289-409; 50090-3945; 31722-146; 71093-130; 67046-554; 50090-3153; 71335-0808; 53869-4960; 68071-1318; 55154-4687; 58118-0834; 53002-2507; 55154-4692; 62350-0043; 70934-190; 71610-435; 71335-0403; 53104-7578; 16729-217; 43063-754; 68071-4370; 70518-1748; 16714-613; 68788-6835; 72789-013; 70518-2448; 70934-169; 71093-131; 0049-4910; 70518-1913; 68645-521; 69097-834; 72865-207; 53869-4910; 63187-795; 31722-145; 60760-612; 43602-981; 16714-601; 71205-047; 50090-2609; 71335-1078; 77777-108; 71335-0718; 16729-215; 52427-672; 68071-1317; 71335-0510; 0143-9655; 70518-2812; 68788-6437; 0049-0050; 68071-4750; 50090-3947; 69097-835; 63187-767; 60687-231; 50436-0215; 71335-0896; 42708-092; 55111-968; 70518-2706; 53002-1215; 72789-092; 52427-664; 16714-611; 68645-523; 55700-562; 68071-4494; 68645-522
Synonyms Sertraline | Zoloft | Altruline | Lustral | Apo-Sertraline | Apo Sertraline | Aremis | Besitran | Sealdin | Gladem | Novo-Sertraline | Novo Sertraline | ratio-Sertraline | ratio Sertraline | Rhoxal-sertraline | Rhoxal sertraline | Sertraline Hydrochloride | Hydrochloride, Sertraline | Sertraline Hydrochloride (1S-cis)-Isomer | Gen-Sertraline | Gen Sertraline
Chemical Information
Molecular Formula C17H18Cl3N
CAS Registry Number 79559-97-0
SMILES CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Nightmare19.02.03.003--Not Available
Nocturia20.02.03.001--Not Available
Non-Hodgkin's lymphoma16.35.01.001; 01.17.01.001--Not Available
Nystagmus17.02.02.006; 06.05.02.006--
Obsessive-compulsive personality disorder19.05.04.001--Not Available
Oculogyric crisis06.05.02.002; 17.01.03.002--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Oesophagitis07.08.05.001--
Oliguria20.01.03.004--Not Available
Optic neuritis17.04.05.001; 10.04.10.002; 06.04.08.002--Not Available
Orthostatic hypotension24.06.03.004; 17.05.01.020--Not Available
Osteoarthritis15.01.04.001--Not Available
Otitis media11.01.05.004; 04.05.01.001--
Pain08.01.08.004--
Pallor08.01.03.032; 24.03.04.001; 23.03.03.031--Not Available
Palpitations02.01.02.003--
Pancreatitis07.18.01.001--
Pancytopenia01.03.03.003--Not Available
Paraesthesia17.02.06.005--
Paranoia19.05.01.005--Not Available
Peptic ulcer07.04.07.001--Not Available
Peptic ulcer haemorrhage24.07.02.015; 07.04.07.002--Not Available
Periorbital oedema23.04.01.002; 10.01.05.010; 06.08.03.017--
Peripheral ischaemia24.04.03.002--
Peritoneal haemorrhage24.07.02.016; 07.07.02.001--Not Available
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Photophobia17.17.02.006; 06.01.01.004--
Photosensitivity reaction23.03.09.003--
Pollakiuria20.02.02.007--
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