Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sertraline
Drug ID BADD_D02010
Description Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Indications and Usage It may be used for premature ejaculation and vascular headaches as off-label indications.
Marketing Status Prescription; Discontinued
ATC Code N06AB06
DrugBank ID DB01104
KEGG ID D02360
MeSH ID D020280
PubChem ID 68617
TTD Drug ID D0K0TC
NDC Product Code 0904-6925; 68180-352; 63187-478; 70518-2512; 0904-6924; 70518-1461; 70518-1040; 70518-0153; 0904-6926; 50090-3562; 43353-817; 68180-353; 50090-5848; 43353-809; 0615-7990; 67296-1199; 63187-055; 0615-7989; 71335-0404; 68645-589; 70518-0378; 50090-0989; 0615-7991; 68180-351; 68788-7329; 63187-212; 68071-4400; 76282-212; 76282-213; 70518-1617; 65427-009; 76282-214
Synonyms Sertraline | Zoloft | Altruline | Lustral | Apo-Sertraline | Apo Sertraline | Aremis | Besitran | Sealdin | Gladem | Novo-Sertraline | Novo Sertraline | ratio-Sertraline | ratio Sertraline | Rhoxal-sertraline | Rhoxal sertraline | Sertraline Hydrochloride | Hydrochloride, Sertraline | Sertraline Hydrochloride (1S-cis)-Isomer | Gen-Sertraline | Gen Sertraline
Chemical Information
Molecular Formula C17H17Cl2N
CAS Registry Number 79617-96-2
SMILES CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Altered state of consciousness19.07.01.003; 17.02.04.0010.000302%Not Available
Alveolitis allergic22.01.01.002; 10.01.03.0080.000091%Not Available
Amblyopia06.02.01.0010.000060%Not Available
Amenorrhoea21.01.02.001; 05.05.01.0020.000544%
Amnesia19.20.01.001; 17.03.02.0010.001270%
Amylase increased13.05.01.0090.000060%
Anaemia01.03.02.001--
Anaemia neonatal18.04.03.002; 01.03.02.0110.000151%Not Available
Anal atresia07.13.05.001; 03.04.06.0010.000071%Not Available
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Anencephaly17.19.03.001; 03.10.03.0010.000393%Not Available
Anger19.04.02.0010.000725%Not Available
Angina pectoris02.02.02.002; 24.04.04.002--
Angioedema23.04.01.001; 10.01.05.009--Not Available
Angle closure glaucoma06.03.01.0010.000212%Not Available
Anhedonia19.15.02.0070.000635%Not Available
Anorgasmia19.08.01.0010.000907%
Anosmia22.04.03.006; 17.04.04.0010.000272%
Anticholinergic syndrome17.05.01.0010.000091%Not Available
Antisocial behaviour19.05.01.0100.000016%Not Available
Anuria20.01.03.0020.000151%Not Available
Anxiety19.06.02.0020.007919%
Aortic stenosis24.04.01.0010.000121%Not Available
Aortic valve incompetence02.07.03.0010.000272%Not Available
Apathy19.04.04.0020.000786%Not Available
Apgar score low13.15.01.0120.000725%Not Available
Aphasia19.21.01.001; 17.02.03.0010.000605%
Aphthous ulcer07.05.06.0020.000091%Not Available
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