Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Salmeterol
Drug ID BADD_D01981
Description Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol].[A190459] Salmeterol was first described in the literature in 1988.[A190477] Salmeterol's structure is similar to salbutamol's with an aralkyloxy-alkyl substitution on the amine.[A183737] Salmeterol was granted FDA approval on 4 February 1994.[L11542]
Indications and Usage For the treatment of asthma and chronic obstructive pulmonary disease (COPD).
Marketing Status Prescription; Discontinued
ATC Code R03AC12
DrugBank ID DB00938
KEGG ID D05792
MeSH ID D000068299
PubChem ID 5152
TTD Drug ID D0L5YV
NDC Product Code 63850-3912
Synonyms Salmeterol Xinafoate | Xinafoate, Salmeterol | Salmeterol | Serevent
Chemical Information
Molecular Formula C25H37NO4
CAS Registry Number 89365-50-4
SMILES C1=CC=C(C=C1)CCCCOCCCCCCNCC(C2=CC(=C(C=C2)O)CO)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Surgical and medical proceduresBeta-2 adrenergic receptorP07550T5252211804270; 11586955; 10988267; 10984540; 11306963; 10340917; 9399966
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Rash23.03.13.001--Not Available
Respiratory failure14.01.04.003; 22.02.06.0020.003901%
Rhinitis11.01.13.004; 22.07.03.006--
Rhinitis allergic22.04.04.003; 10.01.04.003--
Rhinorrhoea22.02.05.010--
Sinus congestion22.04.06.001--Not Available
Sinus headache22.02.05.023; 17.14.01.002--
Sinusitis11.01.13.005; 22.07.03.007--
Sleep disorder19.02.04.001--Not Available
Sneezing22.02.05.011--
Stridor22.04.02.003--
Supraventricular tachycardia02.03.03.012--
Swelling08.01.03.015--Not Available
Tachycardia02.03.02.007--Not Available
Tenderness08.01.08.005--Not Available
Tension19.06.02.005--Not Available
Throat irritation22.02.05.013; 07.05.03.004--Not Available
Toothache07.09.06.001--
Tracheitis22.07.03.009; 11.01.13.007--
Tracheobronchitis22.07.03.010; 11.01.13.008--Not Available
Tremor17.01.06.0020.014955%
Type I hypersensitivity10.01.03.006--Not Available
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
Urinary tract infection11.01.14.004; 20.08.02.001--
Urticaria23.04.02.001; 10.01.06.001--
Varicella23.09.03.003; 11.05.02.004--Not Available
Ventricular tachycardia02.03.04.010--
Viral infection11.05.04.001--Not Available
Vomiting07.01.07.003--
Viral diarrhoea11.05.04.012; 07.19.02.008--Not Available
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