Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ropinirole hydrochloride
Drug ID BADD_D01967
Description Ropinirole, also known as _ReQuip_, is a non-ergoline dopamine agonist used in Parkinson's disease and restless legs syndrome [FDA label], [A174547]. It is manufactured by GlaxoSmithKline Pharmaceuticals. Ropinirole was initially approved in 1997 by the FDA [FDA label] for the management of Parkinson's disease. In 2005, it was the first drug approved in the US for the management of primary moderate to severe restless legs syndrome [A174547]. In 2008, the extended-release capsules of ropinirole were approved, allowing for less frequent dosing, therefore increased compliance, and offering a similar side effect profile and efficacy to previous formulations of ropinirole [A35711].
Indications and Usage For the treatment of the signs and symptoms of idiopathic Parkinson's disease. Also used for the treatment of restless legs syndrome.
Marketing Status Prescription; Discontinued
ATC Code N04BC04
DrugBank ID DB00268
KEGG ID D00784
MeSH ID C046649
PubChem ID 68727
TTD Drug ID D0R9EQ
NDC Product Code 46708-034; 63629-7152; 62332-031; 46708-036; 50090-4810; 43547-268; 0904-6373; 43547-600; 43547-269; 46708-031; 62332-035; 65096-0102; 54752-0005; 46708-032; 62332-034; 62332-033; 65841-714; 0615-8191; 0615-8190; 71335-1626; 62332-032; 61919-564; 65841-716; 46708-030; 62332-030; 43547-601; 65841-713; 0904-6374; 50090-3304; 43547-596; 0615-8188; 70518-2476; 43547-597; 55111-091; 60687-588; 63629-4798; 43547-595; 62147-0015; 60687-577; 46708-869; 43547-271; 61187-008; 58032-0133; 43547-270; 71335-0727; 43547-274; 43547-599; 0615-8189; 66039-853; 43547-273; 55154-7888; 50090-4348; 71335-0587; 62147-0008; 71335-1434; 65841-715; 46708-035; 51655-360; 43547-598; 65841-712; 62332-036; 55154-7633; 71335-0829; 65841-718; 65841-717; 43547-272; 64220-121; 46708-033
Synonyms ropinirole | 4-(2-(di-n-propylamino)ethyl)-2(3H)-indolone | ropinirol | SK&F 101468 | SKF 101468 | SK&F-101,468 | Requip | ropinirole hydrochloride
Chemical Information
Molecular Formula C16H25ClN2O
CAS Registry Number 91374-20-8
SMILES CCCN(CCC)CCC1=C2CC(=O)NC2=CC=C1.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.002--
Anxiety19.06.02.002--
Asthenia08.01.01.001--Not Available
Back pain15.03.04.005--
Blood pressure increased13.14.03.005--Not Available
Confusional state17.02.03.005; 19.13.01.001--
Constipation07.02.02.001--
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry mouth07.06.01.002--
Dyskinesia17.01.02.006--
Dyspepsia07.01.02.001--
Fall12.01.08.002--
Fatigue08.01.01.002--
Hallucination19.10.02.002--
Headache17.14.01.001--
Heart rate abnormal13.14.04.006--Not Available
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypertension24.08.02.001--
Hypotension24.06.03.002--
Nausea07.01.07.001--
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Orthostatic hypotension24.06.03.004; 17.05.01.020--Not Available
Retinal disorder06.08.03.005--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Syncope24.06.02.012; 17.02.04.008; 02.01.02.008--
Vertigo17.02.12.002; 04.04.01.003--
Viral infection11.05.04.001--Not Available
Adverse event08.06.01.010--Not Available
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