Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Rivaroxaban
Drug ID BADD_D01954
Description Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be taken with food. FDA approved on July 1, 2011.
Indications and Usage Not Available
Marketing Status Prescription
ATC Code B01AF01
DrugBank ID DB06228
KEGG ID D07086
MeSH ID D000069552
PubChem ID 9875401
NDC Product Code 50090-3625; 50458-579; 50458-575; 65015-898; 58032-2029; 55154-1424; 53296-0109; 14799-2023; 55111-966; 76072-1008; 47848-039; 55154-1423; 14501-0079; 65727-050; 52286-0025; 59285-009; 65862-971; 16436-0109; 75945-050; 50090-4468; 53104-7730; 50090-3639; 53747-068; 66022-0203; 50090-4469; 50458-580; 64220-176; 63415-0523; 64552-4049; 50458-578; 46708-899; 82513-0001; 66174-0087; 72969-109; 66039-913; 50458-584; 65372-1193; 50458-577; 55154-1422; 69218-0500
Synonyms Rivaroxaban | 5-chloro-N-(((5S)-2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)-1,3-oxazolidin-5-yl)methyl)thiophene-2-carboxamide | Xarelto | BAY 59-7939 | BAY 59 7939 | BAY 597939
Chemical Information
Molecular Formula C19H18ClN3O5S
CAS Registry Number 366789-02-8
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abdominal pain lower07.01.05.010--Not Available
Abdominal pain upper07.01.05.003--
Abdominal tenderness07.01.05.004--Not Available
Abnormal dreams19.02.03.001; Available
Abnormal faeces07.01.03.001--Not Available
Abnormal weight gain14.03.02.010--Not Available
Abortion18.01.01.001--Not Available
Abortion spontaneous18.01.04.001--Not Available
Abscess11.01.08.001--Not Available
Abscess bacterial11.02.01.0270.000140%Not Available
Acne23.02.01.001--Not Available
Activated partial thromboplastin time abnormal13.01.02.0190.000357%Not Available
Activated partial thromboplastin time prolonged13.01.02.0010.011244%
Activated partial thromboplastin time shortened13.01.02.0200.000535%Not Available
Acute abdomen07.01.06.0150.001249%Not Available
Acute hepatic failure09.01.03.001--Not Available
Acute leukaemia16.01.02.001; Available
Acute myeloid leukaemia16.01.05.001; Available
Acute myocardial infarction24.04.04.001; Available
Acute prerenal failure24.06.02.003; Available
Acute pulmonary oedema22.01.03.005; Available
Acute respiratory distress syndrome22.01.03.001--
Acute respiratory failure22.02.06.001; Available
Adenocarcinoma16.16.01.0040.000140%Not Available
Adrenal disorder05.01.03.0010.000535%Not Available
Adrenal haemorrhage12.01.02.006;; Available
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