Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Rifabutin
Drug ID BADD_D01935
Description A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients.
Indications and Usage For the prevention of disseminated Mycobacterium avium complex (MAC) disease in patients with advanced HIV infection.
Marketing Status approved; investigational
ATC Code J04AB04
DrugBank ID DB00615
KEGG ID D00424
MeSH ID D017828
PubChem ID 135398743
TTD Drug ID D05CHI
NDC Product Code 70518-3731; 73309-108; 68180-285; 10135-738; 0013-5301; 59762-1350; 70954-041
UNII 1W306TDA6S
Synonyms Rifabutin | Rifabutine | Ansamycin | Mycobutin | Ansatipine | LM-427 | LM 427 | LM427 | Alfacid | Ansatipin
Chemical Information
Molecular Formula C46H62N4O11
CAS Registry Number 72559-06-9
SMILES CC1C=CC=C(C(=O)N=C2C(=C3C(=C4C2=NC5(N4)CCN(CC5)CC(C)C)C6=C(C(=C3O)C)OC(C6=O)(OC= CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)O)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Nausea07.01.07.0010.106454%
Neutropenia01.02.03.0040.014583%Not Available
Neutrophil count decreased13.01.06.010--
Pain08.01.08.004--
Pancytopenia01.03.03.0030.014583%Not Available
Paraesthesia23.03.03.094; 17.02.06.005--
Pathogen resistance11.01.08.049--Not Available
Platelet count decreased13.01.04.001--
Pruritus23.03.12.001--
Pseudomembranous colitis11.02.02.002; 07.19.01.003--Not Available
Pyrexia08.05.02.0030.071456%
Rash23.03.13.0010.074372%Not Available
Respiratory failure22.02.06.002; 14.01.04.0030.014583%
Seizure17.12.03.001--
Shock24.06.02.002--Not Available
Skin discolouration23.03.03.005--Not Available
Skin disorder23.03.03.007--Not Available
Testicular atrophy05.05.02.004; 21.13.01.001--Not Available
Thrombocytopenia01.08.01.0020.021874%Not Available
Thrombotic thrombocytopenic purpura24.07.06.014; 23.06.01.011; 01.08.01.005--
Urticaria10.01.06.001; 23.04.02.0010.081664%
Uveitis10.02.01.023; 06.04.03.0030.058331%
Vomiting07.01.07.0030.056873%
White blood cell count decreased13.01.06.012--
Tubulointerstitial nephritis20.05.02.0020.014583%Not Available
Emotional distress19.04.02.008--Not Available
Lymphatic disorder01.09.01.003--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Blood alkaline phosphatase increased13.04.02.004--
Hepatic enzyme increased13.03.04.028--Not Available
The 3th Page    First    Pre   3 4    Next   Last    Total 4 Pages