Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ranolazine
Drug ID BADD_D01915
Description Chronic angina is a common cardiovascular condition affecting millions worldwide and causes significant disability while interfering with daily activities.[A189234] Ranolazine is a well-tolerated piperazine derivative used for the management of this condition, offering relief from uncomfortable and debilitating symptoms.[L3580] With a mechanism of action different from drugs used to treat the same condition, ranolazine is a promising anti-anginal therapy. It was originally approved by the FDA in 2006.[L5440]
Indications and Usage For the treatment of chronic angina. It should be used in combination with amlodipine, beta-blockers or nitrates.
Marketing Status Prescription; Discontinued
ATC Code C01EB18
DrugBank ID DB00243
KEGG ID D05700
MeSH ID D000069458
PubChem ID 56959
TTD Drug ID D03HYQ
NDC Product Code 65841-034; 47335-625; 50228-423; 43353-880; 51407-225; 67877-525; 50370-0019; 67877-526; 50228-424; 69097-222; 70625-206; 45963-418; 68462-320; 47335-624; 71610-518; 51604-1154; 65862-981; 68462-319; 15308-0718; 69367-294; 27241-126; 61958-1003; 48087-0106; 69367-293; 42291-774; 63304-017; 48087-0082; 53747-042; 69097-221; 65162-379; 71610-322; 27241-125; 71205-868; 45963-419; 61958-1004; 51407-226; 71205-867; 68180-355; 42385-964; 67651-0258; 70756-703; 42571-325; 70756-704; 72578-064; 63304-018; 68180-354; 42291-773; 66039-943; 73680-0012; 11014-0108; 62512-0076; 72640-001; 42571-324; 47621-304; 67835-0011; 42385-963; 63552-143; 64552-4024; 63552-142; 67651-0224; 65372-1190; 70966-0008; 40006-043; 70771-1499; 72578-065; 60687-549; 70625-207; 70771-1500; 65162-376
Synonyms Ranolazine | N-(2,6-dimethylphenyl)-4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)-1-piperazineacetamide | Renolazine | Ranolazine Hydrochloride | Hydrochloride, Ranolazine | Ranolazine Dihydrochloride | Dihydrochloride, Ranolazine | Ranolazine HCl | HCl, Ranolazine | Ranexa | RS 43285-193 | RS 43285 193 | RS 43285193 | RS 43285 | 43285, RS | RS-43285 | RS43285
Chemical Information
Molecular Formula C24H33N3O4
CAS Registry Number 95635-55-5
SMILES CC1=C(C(=CC=C1)C)NC(=O)CN2CCN(CC2)CC(COC3=CC=CC=C3OC)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Mental impairment19.21.02.003; 17.03.03.0020.002148%Not Available
Mitral valve incompetence02.07.01.0020.001432%Not Available
Multiple sclerosis17.16.01.001; 10.04.10.0080.001432%Not Available
Muscle spasms15.05.03.004--
Muscle twitching15.05.03.0050.001432%Not Available
Muscular weakness17.05.03.005; 15.05.06.0010.008592%
Myalgia15.05.02.001--
Myasthenia gravis17.05.04.001; 15.05.08.001; 10.04.05.0010.001432%
Myocardial infarction24.04.04.009; 02.02.02.0070.005230%
Myocardial ischaemia24.04.04.010; 02.02.02.0080.000374%Not Available
Myoclonus17.02.05.0080.003580%Not Available
Myopathy15.05.05.0010.002864%Not Available
Nausea07.01.07.0010.038666%
Neck pain15.03.04.0090.001432%
Neoplasm malignant16.16.01.0010.001308%Not Available
Nephropathy toxic20.05.03.002; 12.03.01.010--Not Available
Nervous system disorder17.02.10.001--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Nightmare19.02.03.0030.005012%Not Available
Oedema14.05.06.010; 08.01.07.0060.005012%Not Available
Oedema peripheral02.05.04.007; 14.05.06.011; 08.01.07.0070.009309%
Orthostatic hypotension24.06.03.004; 17.05.01.0200.005728%Not Available
Pain08.01.08.004--
Pain in extremity15.03.04.010--
Palpitations02.01.02.0030.010741%
Pancreatitis07.18.01.001--
Pancytopenia01.03.03.003--Not Available
Paraesthesia17.02.06.005--
Parosmia17.04.04.002; 22.04.03.007--Not Available
Peripheral coldness24.04.03.006; 08.01.09.0100.001432%Not Available
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