Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ranolazine
Drug ID BADD_D01915
Description Chronic angina is a common cardiovascular condition affecting millions worldwide and causes significant disability while interfering with daily activities.[A189234] Ranolazine is a well-tolerated piperazine derivative used for the management of this condition, offering relief from uncomfortable and debilitating symptoms.[L3580] With a mechanism of action different from drugs used to treat the same condition, ranolazine is a promising anti-anginal therapy. It was originally approved by the FDA in 2006.[L5440]
Indications and Usage For the treatment of chronic angina. It should be used in combination with amlodipine, beta-blockers or nitrates.
Marketing Status Prescription; Discontinued
ATC Code C01EB18
DrugBank ID DB00243
KEGG ID D05700
MeSH ID D000069458
PubChem ID 56959
TTD Drug ID D03HYQ
NDC Product Code 65841-034; 47335-625; 50228-423; 43353-880; 51407-225; 67877-525; 50370-0019; 67877-526; 50228-424; 69097-222; 70625-206; 45963-418; 68462-320; 47335-624; 71610-518; 51604-1154; 65862-981; 68462-319; 15308-0718; 69367-294; 27241-126; 61958-1003; 48087-0106; 69367-293; 42291-774; 63304-017; 48087-0082; 53747-042; 69097-221; 65162-379; 71610-322; 27241-125; 71205-868; 45963-419; 61958-1004; 51407-226; 71205-867; 68180-355; 42385-964; 67651-0258; 70756-703; 42571-325; 70756-704; 72578-064; 63304-018; 68180-354; 42291-773; 66039-943; 73680-0012; 11014-0108; 62512-0076; 72640-001; 42571-324; 47621-304; 67835-0011; 42385-963; 63552-143; 64552-4024; 63552-142; 67651-0224; 65372-1190; 70966-0008; 40006-043; 70771-1499; 72578-065; 60687-549; 70625-207; 70771-1500; 65162-376
Synonyms Ranolazine | N-(2,6-dimethylphenyl)-4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)-1-piperazineacetamide | Renolazine | Ranolazine Hydrochloride | Hydrochloride, Ranolazine | Ranolazine Dihydrochloride | Dihydrochloride, Ranolazine | Ranolazine HCl | HCl, Ranolazine | Ranexa | RS 43285-193 | RS 43285 193 | RS 43285193 | RS 43285 | 43285, RS | RS-43285 | RS43285
Chemical Information
Molecular Formula C24H33N3O4
CAS Registry Number 95635-55-5
SMILES CC1=C(C(=CC=C1)C)NC(=O)CN2CCN(CC2)CC(COC3=CC=CC=C3OC)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Electrocardiogram abnormal13.14.05.0010.001432%Not Available
Electrocardiogram QT prolonged13.14.05.0040.016469%
Eosinophilia01.02.04.001--
Epistaxis24.07.01.005; 22.04.03.001--
Erythema23.03.06.001--Not Available
Eye disorder06.08.03.001--Not Available
Eye haemorrhage24.07.05.002; 06.07.02.0010.001432%Not Available
Fatigue08.01.01.002--
Feeling abnormal08.01.09.0140.008592%Not Available
Feeling hot08.01.09.0090.001432%Not Available
Feeling jittery08.01.09.0160.001432%Not Available
Flatulence07.01.04.002--
Gait disturbance17.02.05.016; 08.01.02.0020.007876%
Gastrooesophageal reflux disease07.02.02.0030.003580%
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Gastrointestinal pain07.01.05.005--
Generalised tonic-clonic seizure17.12.01.0020.001432%Not Available
Glomerular filtration rate decreased13.13.01.0090.002148%Not Available
Gout15.01.06.001; 14.09.01.0010.002864%Not Available
Haematochezia24.07.02.012; 07.12.02.0030.002148%Not Available
Haematuria24.07.01.047; 20.02.01.0060.009309%
Blood urine present13.13.02.0020.003580%Not Available
Hallucination19.10.02.0020.012173%
Hallucination, auditory19.10.02.0030.002148%Not Available
Hallucination, visual19.10.02.0040.003580%Not Available
Headache17.14.01.001--
Heart rate decreased13.14.04.0010.001432%Not Available
Heart rate increased13.14.04.002--Not Available
Hernia08.01.04.0010.001432%Not Available
The 4th Page    First    Pre   4 5 6 7 8    Next   Last    Total 10 Pages