Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Rabeprazole sodium
Drug ID BADD_D01899
Description Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion.
Indications and Usage For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use.
Marketing Status Prescription; Discontinued
ATC Code A02BC04
DrugBank ID DB01129
KEGG ID D00724
MeSH ID D064750
PubChem ID 14720269
TTD Drug ID D0KL4J
NDC Product Code 65372-1132; 70518-2590; 45865-802; 71335-0027; 72189-169; 50090-4751; 50090-1424; 71335-1558; 65862-721; 51407-184; 51148-005; 71205-603; 70518-3209; 60760-560; 51148-006; 50090-3145; 68788-7459; 52932-0736; 65862-414; 76420-107; 62856-243; 60760-972; 63187-555; 63187-788; 65977-0033; 50090-3430; 45865-123; 52286-0017; 80425-0134; 55700-767; 53069-0650; 72189-142; 71335-0244; 72888-059; 53104-7568; 71205-292; 55111-055; 80425-0094; 13668-107; 70518-2860; 68180-220; 50090-3182; 42765-013; 71335-0518; 67877-443; 61919-467; 63187-259; 68788-7657; 62175-302; 71335-1100; 53069-0980
Synonyms Rabeprazole | 2-((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methylsulfinyl)-1H-benzimidazole | Dexrabeprazole | E 3810 | E3810 | Pariet | Rabeprazole Sodium | Sodium, Rabeprazole | 1H-Benzimidazole, 2-(((4-(3-methoxypropoxy)-3-methyl-2-pyridinyl)methyl)sulfinyl)-, Sodium Salt | Aciphex | LY-307640 | LY 307640 | LY307640
Chemical Information
Molecular Formula C18H20N3NaO3S
CAS Registry Number 117976-90-6
SMILES CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3[N-]2)OCCCOC.[Na+]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Pain08.01.08.004--
Pancytopenia01.03.03.003--Not Available
Pharyngitis11.01.13.003; 07.05.07.004; 22.07.03.004--
Prothrombin time prolonged13.01.02.012--Not Available
Rhabdomyolysis15.05.05.002--
Stevens-Johnson syndrome23.03.01.007; 12.03.01.014; 11.07.01.005; 10.01.03.020--
Sudden death02.03.04.013; 08.04.01.003--
Thrombocytopenia01.08.01.002--Not Available
Toxic epidermal necrolysis23.03.01.008; 12.03.01.015; 10.01.01.006; 11.07.01.006--
Vomiting07.01.07.003--
Tubulointerstitial nephritis20.05.02.002--Not Available
Dermatologic examination abnormal13.15.01.019--Not Available
Hepatic enzyme increased13.03.01.019--Not Available
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