Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Rabeprazole
Drug ID BADD_D01898
Description Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion.
Indications and Usage For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use.
Marketing Status approved; investigational
ATC Code A02BC04
DrugBank ID DB01129
KEGG ID D08463
MeSH ID D064750
PubChem ID 5029
TTD Drug ID D0KL4J
NDC Product Code 65162-724
UNII 32828355LL
Synonyms Rabeprazole | 2-((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methylsulfinyl)-1H-benzimidazole | Dexrabeprazole | E 3810 | E3810 | Pariet | Rabeprazole Sodium | Sodium, Rabeprazole | 1H-Benzimidazole, 2-(((4-(3-methoxypropoxy)-3-methyl-2-pyridinyl)methyl)sulfinyl)-, Sodium Salt | Aciphex | LY-307640 | LY 307640 | LY307640
Chemical Information
Molecular Formula C18H21N3O3S
CAS Registry Number 117976-89-3
SMILES CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCCCOC
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pelvic pain21.10.01.001; 20.02.03.007; 07.01.06.012--
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Photosensitivity reaction23.03.09.0030.000573%
Platelet disorder01.08.03.001--Not Available
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Pollakiuria20.02.02.007--
Polyuria20.02.03.002--Not Available
Premature baby18.04.02.001--Not Available
Proctitis07.08.04.001--
Prostatic disorder21.04.01.001--Not Available
Prostatic specific antigen increased13.23.01.003--Not Available
Pruritus23.03.12.0010.002447%
Psoriasis23.03.14.002; 10.02.01.036--Not Available
Pulmonary embolism24.01.06.001; 22.06.02.001--Not Available
Pyrexia08.05.02.0030.003619%
Rash23.03.13.001--Not Available
Rash pruritic23.03.13.0300.000391%Not Available
Rectal haemorrhage07.12.03.001; 24.07.02.018--
Renal failure20.01.03.0050.000651%Not Available
Renal tubular disorder20.05.03.0040.000911%Not Available
Respiratory failure22.02.06.002; 14.01.04.003--
Retching07.01.07.002--Not Available
Retinal degeneration06.09.03.002--Not Available
Retinal disorder06.08.03.005--Not Available
Rhabdomyolysis15.05.05.0020.000391%
Rheumatoid arthritis15.01.03.001; 10.04.06.001--Not Available
Rhinitis22.07.03.006; 11.01.13.004--
Rhinorrhoea22.12.03.021--
Salivary gland enlargement07.06.03.002--Not Available
Seborrhoeic dermatitis23.03.04.018--Not Available
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