Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Quinidine gluconate
Drug ID BADD_D01893
Description An optical isomer of [quinine], extracted from the bark of the Cinchona tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular action potential, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.
Indications and Usage For the treatment of ventricular pre-excitation and cardiac dysrhythmias
Marketing Status Prescription; Discontinued
ATC Code C01BA01
DrugBank ID DB00908
KEGG ID D00642
MeSH ID C016713
PubChem ID 94328
TTD Drug ID Not Available
NDC Product Code 53489-141; 51407-288; 54738-901; 12065-1702
Synonyms quinidine gluconate | quinidine gluconate, (9S)-isomer | quinidine gluconate, (8alpha,9R)-isomer | Quinact | Quinaglute
Chemical Information
Molecular Formula C26H36N2O9
CAS Registry Number 6587-33-3
SMILES COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.C(C(C(C(C(C(=O)O)O)O)O)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Acute psychosis19.03.01.001--Not Available
Agranulocytosis01.02.03.001--Not Available
Angina pectoris24.04.04.002; 02.02.02.002--
Angioedema23.04.01.001; 10.01.05.009--Not Available
Anxiety19.06.02.002--
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Ataxia17.02.02.001; 08.01.02.004--
Bronchospasm22.03.01.004; 10.01.03.012--
Cinchonism12.03.01.034--Not Available
Colour blindness06.02.09.001; 03.01.01.001--Not Available
Coordination abnormal17.02.02.004--Not Available
Depression19.15.01.001--
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Fatigue08.01.01.002--
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Granulomatous liver disease09.01.07.001--Not Available
Haemolytic anaemia01.06.03.002--Not Available
Headache17.14.01.001--
Hepatotoxicity12.03.01.008; 09.01.07.009--Not Available
Lymphadenopathy01.09.01.002--Not Available
Myalgia15.05.02.001--
Mydriasis17.02.11.003; 06.05.03.004--Not Available
Nervousness19.06.02.003--Not Available
Night blindness14.12.03.001; 06.02.02.003--
Optic neuritis17.04.05.001; 10.04.10.002; 06.04.08.002--Not Available
Palpitations02.01.02.003--
Photosensitivity reaction23.03.09.003--
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