Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Quinapril
Drug ID BADD_D01890
Description Quinapril is the ethyl ester prodrug of the non-sulfhydryl angiotensin converting enzyme inhibitor quinaprilat.[L8420,L8423] It is used to treat hypertension and heart failure.[L8420,L8423] ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta blockers.[A184844] Quinapril was granted FDA approval on 19 November 1991.[L8420] A combination tablet with [hydrochlorothiazide] was also approved on 28 December 1999.[L8423]
Indications and Usage Quinapril is indicated for the treatment of hypertension and as an adjunct therapy in the treatment of heart failure.[L8420] Quinapril in combination with hydrochlorothiazide is indicated for the treatment of hypertension.[L8423]
Marketing Status approved; investigational
ATC Code C09AA06
DrugBank ID DB00881
KEGG ID D03752
MeSH ID D000077583
PubChem ID 54892
TTD Drug ID D0I7SZ
NDC Product Code 50090-5165; 68001-260; 50090-5400; 68084-899; 69097-841; 71335-1262; 57297-555; 69097-839; 71335-1134; 71335-1441; 43547-412; 68180-557; 70934-964; 68001-189; 69097-843; 71205-635; 63187-425; 63629-8710; 68001-188; 71205-484; 68001-187; 68180-554; 68180-556; 71335-1707; 51655-737; 68180-558; 69097-842; 43547-411; 43547-413
UNII RJ84Y44811
Synonyms Quinapril | 2-(2-((1-(Ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid | Accupril | CI 906 | CI-906 | Quinapril Hydrochloride | PD 109452-2 | PD 109452 2 | PD 1094522 | PD-109,452-2 | PD 109,452 2
Chemical Information
Molecular Formula C25H30N2O5
CAS Registry Number 85441-61-8
SMILES CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2CC3=CC=CC=C3CC2C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Haemolytic anaemia01.06.03.002--Not Available
Headache17.14.01.001--
Heart rate abnormal13.14.04.006--Not Available
Hepatitis09.01.07.004--Not Available
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hyperkalaemia14.05.03.001--
Hypertension24.08.02.001--
Hypertensive crisis24.08.01.001--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Liver function test abnormal13.03.04.030--Not Available
Malaise08.01.01.003--
Myocardial infarction24.04.04.009; 02.02.02.007--
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Orthostatic hypotension24.06.03.004; 17.05.01.020--Not Available
Palpitations02.11.04.012--
Pancreatitis07.18.01.001--
Paraesthesia23.03.03.094; 17.02.06.005--
Pemphigus23.03.01.005; 10.04.02.003--Not Available
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Photosensitivity reaction23.03.09.003--
Pruritus23.03.12.001--
Rash23.03.13.001--Not Available
Renal failure20.01.03.005--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Syncope02.11.04.015; 24.06.02.012; 17.02.04.008--
Tachycardia02.03.02.007--Not Available
Thrombocytopenia01.08.01.002--Not Available
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ADReCS-Target
Drug Name ADR Term Target
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