Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Quinapril
Drug ID BADD_D01890
Description Quinapril is the ethyl ester prodrug of the non-sulfhydryl angiotensin converting enzyme inhibitor quinaprilat.[L8420,L8423] It is used to treat hypertension and heart failure.[L8420,L8423] ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta blockers.[A184844] Quinapril was granted FDA approval on 19 November 1991.[L8420] A combination tablet with [hydrochlorothiazide] was also approved on 28 December 1999.[L8423]
Indications and Usage For the treatment of hypertension and as adjunct therapy in the treatment of congestive heart failure. May also be used to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy.
Marketing Status Prescription; Discontinued
ATC Code C09AA06
DrugBank ID DB00881
KEGG ID D03752
MeSH ID D000077583
PubChem ID 54892
TTD Drug ID D0I7SZ
NDC Product Code 43547-413; 50090-5400; 68001-188; 68084-899; 63629-8710; 57297-555; 69097-841; 71335-1441; 43547-411; 71205-484; 50090-5165; 68001-189; 69097-842; 71335-1262; 69097-839; 68001-187; 63187-425; 71335-1134; 50090-5487; 71205-635; 71335-1707; 43547-410; 68180-554; 68180-558; 69097-843; 68001-260; 50090-4649; 68180-557; 68180-556; 43547-412
Synonyms Quinapril | 2-(2-((1-(Ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid | Accupril | CI 906 | CI-906 | Quinapril Hydrochloride | PD 109452-2 | PD 109452 2 | PD 1094522 | PD-109,452-2 | PD 109,452 2
Chemical Information
Molecular Formula C25H30N2O5
CAS Registry Number 85441-61-8
SMILES CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2CC3=CC=CC=C3CC2C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Blood pressure decreasedAngiotensin-converting enzymeP12821T8257716395257; 16138565; 9270093; 10535720; 9726242; 10620209; 10880412; 8986921; 10999650
CoughB2 bradykinin receptorP30411T2371410904024; 12522467; 11699055; 15894833
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Agranulocytosis01.02.03.001--Not Available
Alopecia23.02.02.001--
Amblyopia06.02.01.001--Not Available
Anaphylactic reaction24.06.03.006; 10.01.07.0010.000344%
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Angina pectoris02.02.02.002; 24.04.04.002--
Angioedema23.04.01.001; 10.01.05.0090.008347%Not Available
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Back pain15.03.04.005--
Blood creatinine increased13.13.01.004--
Blood pressure abnormal13.14.03.0010.000879%Not Available
Blood pressure increased13.14.03.0050.003075%Not Available
Blood urea increased13.13.01.006--Not Available
Body temperature decreased13.15.01.0100.000879%Not Available
Cardiac failure02.05.01.001--
Cardiogenic shock24.06.02.006; 02.05.01.003--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Constipation07.02.02.001--
Cough22.02.03.0010.005272%
Death08.04.01.001--
Depression19.15.01.001--
Dermatitis exfoliative10.01.01.004; 23.03.07.001--
Dermatomyositis23.03.02.001; 15.05.01.002; 10.04.02.001--Not Available
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.0040.002197%
Drug hypersensitivity10.01.01.0010.027239%Not Available
Dry mouth07.06.01.002--
Dry throat22.02.05.004; 07.06.01.005--Not Available
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