Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Quetiapine
Drug ID BADD_D01888
Description Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder.[L8546] Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable option for some patients with high sensitivity to other drugs, such as [Clozapine] and [Olanzapine].[A2189]
Indications and Usage For the treatment of schizophrenia and related psychotic disorders.
Marketing Status Prescription; Discontinued
ATC Code N05AH04
DrugBank ID DB01224
KEGG ID D08456
MeSH ID D000069348
PubChem ID 5002
TTD Drug ID D0H7KF
NDC Product Code 0615-7987; 50090-2307; 65862-877; 63629-4939; 16714-456; 65862-876; 0310-0275; 71610-538; 0093-8166; 70518-0239; 0093-8164; 71093-139; 65862-874; 33342-136; 63629-2482; 71205-402; 63629-2480; 50228-383; 16729-146; 71335-0432; 63629-2481; 68001-181; 63629-7116; 68001-183; 50090-2831; 50090-2338; 71205-026; 0615-7988; 80425-0107; 0615-8118; 70518-0570; 71205-401; 70518-0752; 16714-457; 50090-2689; 68001-180; 70518-0229; 16729-147; 50090-3749; 16729-148; 0310-0274; 50228-381; 70518-0432; 68788-7412; 50090-5451; 50090-2830; 16729-150; 65862-873; 71093-135; 71093-137; 53002-1529; 68001-182; 0310-0282; 0615-7986; 16714-454; 71093-138; 71093-136; 80425-0143; 68788-7185; 70518-0289; 68788-7186; 0310-0279; 16714-455; 16714-452; 50228-382; 33342-135; 68001-185; 50228-380; 60687-371; 16729-149; 68788-7590; 53002-1516; 65862-875; 33342-134; 0310-0278; 0310-0281; 63629-2478; 60687-338; 50090-4788; 68788-7184; 0093-8162; 0310-0284; 68001-184; 16729-145; 63629-2479; 0615-8119; 16714-453; 33342-137; 70518-2828; 0093-8163; 0310-0283; 68071-4161; 60687-327; 0093-8165; 60687-360; 50228-384; 60687-349; 0093-2063; 60687-382; 0310-0271; 0310-0272; 0310-0280
Synonyms Quetiapine Fumarate | Ethanol, 2-(2-(4-dibenzo(b,f)(1,4)thiazepin-11-yl-1-piperazinyl)ethoxy)-, (E)-2-butenedioate (2:1) (salt) | Seroquel | ICI 204,636 | ICI-204636 | ICI204636 | ICI 204636 | Quetiapine | 2-(2-(4-dibenzo(b,f)(1,4)thiazepine-11-yl-1-piperazinyl)ethoxy)ethanol
Chemical Information
Molecular Formula C21H25N3O2S
CAS Registry Number 111974-69-7
SMILES C1CN(CCN1CCOCCO)C2=NC3=CC=CC=C3SC4=CC=CC=C42
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood albumin decreased13.09.01.0010.000255%Not Available
Blood bicarbonate increased13.11.01.0010.000255%Not Available
Blood bilirubin increased13.03.01.008--
Blood cholesterol increased13.12.01.0020.001274%
Blood cortisol decreased13.10.09.0040.000764%Not Available
Blood creatine phosphokinase increased13.04.01.0010.006750%
Blood creatinine increased13.13.01.004--
Blood gases abnormal13.02.01.0070.000255%Not Available
Blood glucose decreased13.02.02.0010.000509%Not Available
Blood glucose increased13.02.02.002--Not Available
Blood lactate dehydrogenase increased13.04.02.0020.000637%
Blood lactic acid increased13.02.01.0150.000382%Not Available
Blood pH decreased13.02.01.0160.001019%Not Available
Blood potassium decreased13.11.01.010--Not Available
Blood potassium increased13.11.01.0110.000764%Not Available
Blood pressure abnormal13.14.03.0010.000509%Not Available
Blood pressure decreased13.14.03.0020.004330%Not Available
Blood pressure diastolic decreased13.14.03.003--Not Available
Blood pressure fluctuation24.06.01.002--Not Available
Blood pressure increased13.14.03.005--Not Available
Blood prolactin increased13.10.03.0020.001146%Not Available
Blood sodium decreased13.11.01.0120.000637%Not Available
Blood sodium increased13.11.01.0130.000255%Not Available
Blood triglycerides increased13.12.03.0010.001146%Not Available
Blood urea increased13.13.01.0060.000199%Not Available
Body temperature decreased13.15.01.0100.000255%Not Available
Body temperature increased13.15.01.0010.000166%Not Available
Bone pain15.02.01.001--
Bradycardia02.03.02.0020.005095%Not Available
Bradycardia foetal18.03.02.006; 02.03.02.0180.000509%Not Available
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