Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pseudoephedrine
Drug ID BADD_D01876
Description Pseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic nervous system.[A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889.[A188823] The decongestant effect of pseudoephedrine was described in dogs in 1927.[A188823]
Indications and Usage For the treatment of nasal congestion, sinus congestion, Eustachian tube congestion, and vasomotor rhinitis, and as an adjunct to other agents in the optimum treatment of allergic rhinitis, croup, sinusitis, otitis media, and tracheobronchitis. Also used as first-line therapy of priapism.
Marketing Status OTC; Discontinued
ATC Code R01BA02
DrugBank ID DB00852
KEGG ID D08449
MeSH ID D054199
PubChem ID 7028
TTD Drug ID D00HHS
NDC Product Code 57218-500
Synonyms Pseudoephedrine | Pseudoephedrine Hydrochloride | Pseudoephedrine HCl | Sudafed | Isoephedrine | Threo Isomer of Ephedrine | Ephedrine Threo Isomer
Chemical Information
Molecular Formula C10H15NO
CAS Registry Number 90-82-4
SMILES CC(C(C1=CC=CC=C1)O)NC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Palpitations02.01.02.0030.003681%
Pruritus23.03.12.0010.001052%
Psychomotor hyperactivity19.11.02.003; 17.01.02.0110.001052%Not Available
Pyrexia08.05.02.0030.001052%
Rash23.03.13.001--Not Available
Rash erythematous23.03.06.0030.001052%Not Available
Restlessness19.11.02.002; 17.02.05.0210.001052%
Swelling face23.04.01.018; 10.01.05.0180.001052%Not Available
Tachycardia02.03.02.0070.001578%Not Available
Tremor17.01.06.0020.001052%
Urinary retention20.02.02.0110.001052%
Urticaria23.04.02.001; 10.01.06.0010.001052%
Visual impairment06.02.06.0080.001052%Not Available
Vomiting07.01.07.0030.003681%
Toxic skin eruption10.01.01.008; 23.03.05.0030.001052%Not Available
Cerebral vasoconstriction24.04.06.025; 17.08.02.0120.001052%Not Available
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