Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pseudoephedrine
Drug ID BADD_D01876
Description Pseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic nervous system.[A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889.[A188823] The decongestant effect of pseudoephedrine was described in dogs in 1927.[A188823]
Indications and Usage For the treatment of nasal congestion, sinus congestion, Eustachian tube congestion, and vasomotor rhinitis, and as an adjunct to other agents in the optimum treatment of allergic rhinitis, croup, sinusitis, otitis media, and tracheobronchitis. Also used as first-line therapy of priapism.
Marketing Status OTC; Discontinued
ATC Code R01BA02
DrugBank ID DB00852
KEGG ID D08449
MeSH ID D054199
PubChem ID 7028
TTD Drug ID D00HHS
NDC Product Code 57218-500
Synonyms Pseudoephedrine | Pseudoephedrine Hydrochloride | Pseudoephedrine HCl | Sudafed | Isoephedrine | Threo Isomer of Ephedrine | Ephedrine Threo Isomer
Chemical Information
Molecular Formula C10H15NO
CAS Registry Number 90-82-4
SMILES CC(C(C1=CC=CC=C1)O)NC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain lower07.01.05.0100.001052%Not Available
Agitation19.06.02.001; 17.02.05.012--
Anxiety19.06.02.0020.002104%
Arrhythmia02.03.02.001--Not Available
Blood pressure increased13.14.03.0050.001578%Not Available
Burning sensation17.02.06.001; 08.01.09.0290.001052%Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.0070.001052%
Chest pain02.02.02.011; 22.02.08.003; 08.01.08.0020.001052%Not Available
Colitis ischaemic24.04.08.012; 07.08.01.0040.003155%Not Available
Confusional state19.13.01.001; 17.02.03.0050.001052%
Death08.04.01.001--
Dermatitis23.03.04.002--Not Available
Diarrhoea haemorrhagic07.02.01.002; 24.07.02.0040.001052%Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.0040.002104%
Drug abuse19.07.02.0100.000274%Not Available
Drug hypersensitivity10.01.01.0010.025243%Not Available
Dry mouth07.06.01.0020.001052%
Dry skin23.03.03.0010.001052%
Dyspnoea22.02.01.004; 02.01.03.0020.002104%
Dysuria20.02.02.0020.001052%
Feeling jittery08.01.09.0160.001052%Not Available
Formication19.10.02.010; 17.02.06.0180.001052%Not Available
Hallucination19.10.02.0020.001052%
Headache17.14.01.001--
Heart rate increased13.14.04.0020.002104%Not Available
Hypersensitivity10.01.03.0030.004207%
Hypertension24.08.02.0010.001578%
Insomnia19.02.01.002; 17.15.03.0020.003681%
Loss of consciousness17.02.04.0040.002104%Not Available
Nausea07.01.07.0010.003155%
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