Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Propylthiouracil
Drug ID BADD_D01869
Description A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534)
Indications and Usage Used to manage hyperthyroidism which is due to an overactive thyroid gland (Grave's disease).
Marketing Status Prescription; Discontinued
ATC Code H03BA02
DrugBank ID DB00550
KEGG ID D00562
MeSH ID D011441
PubChem ID 657298
TTD Drug ID D00MIN
NDC Product Code 20012-0001; 49452-6112; 65319-1059; 68084-964; 51927-0163; 51927-1183; 59348-0013; 70752-171; 67253-651; 0228-2348
Synonyms Propylthiouracil | 6-Propyl-2-Thiouracil | 6 Propyl 2 Thiouracil
Chemical Information
Molecular Formula C7H10N2OS
CAS Registry Number 51-52-5
SMILES CCCC1=CC(=O)NC(=S)N1
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
VasculitisMitochondrial substrate carrier family protein ancAO97470Not Available9181282; 11250767; 8103148; 15746603; 15473130; 15138182; 12507274; 15730621
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Haematuria24.07.01.047; 20.02.01.0060.016396%
Haemoglobin13.01.05.018--Not Available
Haemoptysis02.01.02.006; 24.07.01.006; 22.02.03.0040.021861%Not Available
Headache17.14.01.001--
Hepatic encephalopathy17.13.01.003; 09.01.03.0060.002851%Not Available
Hepatic failure09.01.03.0020.007129%
Hepatitis09.01.07.004--Not Available
Hypersensitivity10.01.03.0030.016396%
Hypersensitivity vasculitis24.05.02.012; 23.06.02.005; 10.02.02.017; 01.01.04.0080.008554%Not Available
Hyperthyroidism14.11.01.011; 05.02.02.0010.016396%
Hypoprothrombinaemia01.01.01.001--Not Available
Hypothyroidism14.11.01.012; 05.02.03.0010.010931%
Interstitial lung disease22.01.02.003; 10.02.01.033--Not Available
Jaundice01.06.04.004; 23.03.03.030; 09.01.01.0040.027327%Not Available
Leukopenia01.02.02.001--Not Available
Lung infiltration22.01.02.004--Not Available
Lymphadenopathy01.09.01.002--Not Available
Malaise08.01.01.0030.010931%
Myalgia15.05.02.001--
Nausea07.01.07.0010.027327%
Nephritis20.05.02.001--Not Available
Neuritis17.09.03.001--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Pancytopenia01.03.03.0030.016396%Not Available
Paraesthesia17.02.06.005--
Pleural effusion22.05.02.0020.016396%
Pneumonia22.07.01.003; 11.01.09.0030.010931%Not Available
Polyhydramnios18.05.01.0020.010931%Not Available
Premature baby18.04.02.0010.021861%Not Available
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