Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Propranolol hydrochloride
Drug ID BADD_D01868
Description Propranolol is a racemic mixture of 2 enantiomers where the S(-)-enantiomer has approximately 100 times the binding affinity for beta adrenergic receptors.[L6904] Propranolol is used to treat a number of conditions but most commonly is used for hypertension.[L6901,L6904,L6907] Propranolol was granted FDA approval on 13 November 1967.[L6904]
Indications and Usage For the prophylaxis of migraine.
Marketing Status Prescription; Discontinued
ATC Code C07AA05
DrugBank ID DB00571
KEGG ID D00483
MeSH ID D011433
PubChem ID 62882
TTD Drug ID D04JEE
NDC Product Code 63187-839; 70518-0287; 68382-162; 22568-1027; 42291-522; 70518-0164; 68382-161; 68071-4794; 60429-128; 0527-4119; 53002-4561; 51991-820; 60687-215; 62559-522; 0115-1693; 60687-295; 50090-1501; 70518-3377; 72189-322; 70518-3053; 60687-306; 0615-8134; 69292-538; 0615-8413; 70518-1761; 71205-446; 70518-3102; 69237-002; 0591-5554; 0143-9872; 0115-1662; 51407-235; 62559-530; 71205-499; 64370-375; 51991-818; 71335-1765; 69238-2079; 63629-3587; 59917-093; 62559-523; 60760-538; 68788-7791; 42816-0470; 53002-4951; 0527-4116; 60687-609; 60429-127; 0904-6705; 65841-745; 0591-5557; 17856-3728; 0615-8187; 65841-748; 65841-747; 0404-9944; 42291-524; 42816-0473; 63629-1968; 0527-4117; 63629-2275; 62559-532; 71335-0832; 70518-1463; 68788-6855; 0228-2781; 63629-2069; 62559-531; 62559-533; 66219-0007; 62559-590; 0378-0182; 70518-2464; 62559-601; 72189-018; 53002-3600; 57451-1124; 60760-262; 0603-5485; 42816-0479; 0228-2780; 0615-8186; 51991-817; 53002-4950; 60760-545; 60429-126; 62559-521; 42291-525; 0603-5484; 69292-536; 50090-0420; 63629-2282; 66267-261; 51655-426; 70518-1831; 0121-0908; 63629-2280; 69238-2078; 68071-4677; 0378-0185; 71205-590; 42816-0471; 68788-7350; 59917-094; 68788-7860; 63629-2072; 71335-1994; 0591-5556; 0603-5486; 0615-8426; 70518-1041; 71872-7195; 51604-0002; 0591-5555; 63629-2279; 71335-1712; 68382-163; 71335-1120; 0054-3730; 62559-600; 68071-4573; 49452-6089; 62559-520; 43063-647; 63323-604; 0115-1661; 63629-2281; 63629-2277; 43353-084; 59917-095; 57451-1128; 71335-0661; 0603-5483; 69238-2080; 50090-3953; 60687-587; 50090-3296; 51927-1606; 42291-523; 71610-339; 70518-3281; 60687-598; 63629-2278; 71335-0731; 71335-1140; 0904-6550; 70518-2429; 51662-1338; 70518-3141; 55289-233; 68071-2424; 0378-0184; 55700-940; 69238-2081; 43353-961; 53808-1126; 71872-7096; 69292-534; 50268-702; 63629-2882; 0115-1659; 69292-532; 50090-2756; 70518-0022; 71205-185; 71335-0234; 53002-4560; 0527-4118; 51407-236; 51407-239; 51407-238; 50268-701; 52584-872; 0228-2779; 51407-237; 0115-1660; 0603-5482; 63629-2274; 59917-092; 51991-819; 63629-2070; 71335-0955; 60687-226; 69292-530; 0054-3727; 0615-8417; 62559-591; 61919-808; 50090-0146; 0378-0187; 70934-922; 69238-2077; 68071-5071; 70518-0309; 0378-0183; 68071-2484; 50268-700; 0228-2778; 60429-129; 72189-074; 63629-2276; 63629-2071; 51655-348; 65841-746; 70518-0833; 68382-164; 71335-0907
Synonyms Propranolol | Propanolol | Inderal | Avlocardyl | AY-20694 | AY 20694 | AY20694 | Rexigen | Dexpropranolol | Dociton | Obsidan | Obzidan | Propranolol Hydrochloride | Hydrochloride, Propranolol | Anaprilin | Anapriline | Betadren
Chemical Information
Molecular Formula C16H22ClNO2
CAS Registry Number 318-98-9
SMILES CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCytochrome P450 2D6P10635T57392Not Available
BradycardiaCytochrome P450 3A4P08684T37848Not Available
HypotensionCytochrome P450 3A4P08684T37848Not Available
Mitochondrial toxicityCa2+/Mg2+ ATPaseQ63080Not AvailableNot Available
Poisoning and toxicityCytochrome P450 1A1P04798Not AvailableNot Available
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
Sudden cardiac deathPotassium voltage-gated channel subfamily E member 1P15382Not AvailableNot Available
Sudden cardiac deathPotassium voltage-gated channel subfamily H member 2Q12809T20251Not Available
Sudden cardiac deathPotassium voltage-gated channel subfamily KQT member 1P51787T49526Not Available
Sudden cardiac deathSodium channel protein type 5 subunit alphaQ14524T39716Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abnormal dreams19.02.03.001; 17.15.02.001--Not Available
Agranulocytosis01.02.03.001--Not Available
Alopecia23.02.02.001--
Amnesia19.20.01.001; 17.03.02.001--
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Asthenia08.01.01.001--Not Available
Atrioventricular block02.03.01.002--Not Available
Bradycardia02.03.02.002--Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Cardiac failure congestive02.05.01.002--Not Available
Catatonia19.11.01.001--Not Available
Colitis ischaemic24.04.08.012; 07.08.01.004--Not Available
Constipation07.02.02.001--
Depressed level of consciousness17.02.04.002--
Depression19.15.01.001--
Dermatitis exfoliative23.03.07.001; 10.01.01.004--
Diarrhoea07.02.01.001--
Disorientation19.13.01.002; 17.02.05.015--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry eye06.08.02.001--
Dyspepsia07.01.02.001--
Erythema multiforme23.03.01.003; 10.01.03.015--
Fatigue08.01.01.002--
Hallucination19.10.02.002--
Hypersensitivity10.01.03.003--
Hypotension24.06.03.002--
Insomnia19.02.01.002; 17.15.03.002--
Laryngospasm22.04.02.002--
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