Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Propranolol
Drug ID BADD_D01867
Description Propranolol is a racemic mixture of 2 enantiomers where the S(-)-enantiomer has approximately 100 times the binding affinity for beta adrenergic receptors.[L6904] Propranolol is used to treat a number of conditions but most commonly is used for hypertension.[L6901,L6904,L6907] Propranolol was granted FDA approval on 13 November 1967.[L6904]
Indications and Usage For the prophylaxis of migraine.
Marketing Status Prescription; Discontinued
ATC Code C07AA05
DrugBank ID DB00571
KEGG ID D08443
MeSH ID D011433
PubChem ID 4946
TTD Drug ID D04JEE
NDC Product Code Not Available
Synonyms Propranolol | Propanolol | Inderal | Avlocardyl | AY-20694 | AY 20694 | AY20694 | Rexigen | Dexpropranolol | Dociton | Obsidan | Obzidan | Propranolol Hydrochloride | Hydrochloride, Propranolol | Anaprilin | Anapriline | Betadren
Chemical Information
Molecular Formula C16H21NO2
CAS Registry Number 525-66-6
SMILES CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCytochrome P450 2D6P10635T57392Not Available
BradycardiaCytochrome P450 3A4P08684T3784812864757; 15209687; 11999139
BradycardiaCytochrome P450 3A4P08684T3784816634720; 7594046; 8245337; 16770596; 10825413; 7694600
HypotensionCytochrome P450 3A4P08684T3784812864757; 15209687; 11999139
HypotensionCytochrome P450 3A4P08684T3784816634720; 7594046; 8245337; 16770596; 10825413; 7694600
Mitochondrial toxicityCa2+/Mg2+ ATPaseQ63080Not Available3157382; 6324685; 2996181; 7994564; 6713449; 10370869; 2938592; 12498738; 2630100; 6316993
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
Poisoning and toxicityCytochrome P450 1A1P04798Not Available15094323; 11906967; 15224175
Sudden cardiac deathPotassium voltage-gated channel subfamily H member 2Q12809T202519927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily KQT member 1P51787T495269927398; 10810773; 10082151; 10408028
Sudden cardiac deathSodium channel protein type 5 subunit alphaQ14524T397169927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily E member 1P15382Not Available9927398; 10810773; 10082151; 10408028
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gastrointestinal pain07.01.05.005--
Generalised tonic-clonic seizure17.12.01.0020.001139%Not Available
Gingival bleeding24.07.02.010; 07.09.07.0010.000506%Not Available
Glaucoma06.03.01.0020.000253%
Haemangioma24.03.06.004; 16.02.01.0020.000886%Not Available
Haematochezia24.07.02.012; 07.12.02.003--Not Available
Haemoglobin decreased13.01.05.003--Not Available
Haemoptysis22.02.03.004; 02.01.02.006; 24.07.01.006--Not Available
Haemorrhagic stroke24.07.04.014; 17.08.01.0110.000066%Not Available
Hair texture abnormal23.02.06.0040.000066%
Hallucination19.10.02.002--
Hallucination, visual19.10.02.0040.000886%Not Available
Headache17.14.01.001--
Heart rate decreased13.14.04.0010.003671%Not Available
Heart rate increased13.14.04.002--Not Available
Heart rate irregular13.14.04.0030.000253%Not Available
Hemiparesis17.01.04.0010.000506%
Hepatic cirrhosis09.01.04.0010.000099%Not Available
Hepatic congestion09.01.05.008; 02.05.04.0130.000066%Not Available
Hepatic encephalopathy17.13.01.003; 09.01.03.0060.001266%Not Available
Hyperhidrosis23.02.03.004; 08.01.03.0280.004051%
Hyperkalaemia14.05.03.0010.002026%
Hypersensitivity10.01.03.003--
Hypersomnia19.02.05.001; 17.15.01.0010.000253%
Hypertension24.08.02.0010.002532%
Hyperthyroidism14.11.01.011; 05.02.02.0010.000633%
Hypoaesthesia17.02.06.023--Not Available
Hypocalcaemia14.04.01.0040.000253%
Hypoglycaemia14.06.03.001; 05.06.03.0010.007469%
Hypoglycaemia neonatal18.04.06.003; 14.06.03.006; 05.06.03.0060.000380%Not Available
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