Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Propranolol
Drug ID BADD_D01867
Description Propranolol is a racemic mixture of 2 enantiomers where the S(-)-enantiomer has approximately 100 times the binding affinity for beta adrenergic receptors.[L6904] Propranolol is used to treat a number of conditions but most commonly is used for hypertension.[L6901,L6904,L6907] Propranolol was granted FDA approval on 13 November 1967.[L6904]
Indications and Usage Propranolol is indicated to treat hypertension.[L6907,L6904] Propranolol is also indicated to treat angina pectoris due to coronary atherosclerosis, atrial fibrillation, myocardial infarction, migraine, essential tremor, hypertrophic subaortic stenosis, pheochromocytoma, and proliferating infantile hemangioma.[L6904,L6907]
Marketing Status approved; investigational
ATC Code C07AA05
DrugBank ID DB00571
KEGG ID D08443
MeSH ID D011433
PubChem ID 4946
TTD Drug ID D04JEE
NDC Product Code Not Available
UNII 9Y8NXQ24VQ
Synonyms Propranolol | Propanolol | Inderal | Avlocardyl | AY-20694 | AY 20694 | AY20694 | Rexigen | Dexpropranolol | Dociton | Obsidan | Obzidan | Propranolol Hydrochloride | Hydrochloride, Propranolol | Anaprilin | Anapriline | Betadren
Chemical Information
Molecular Formula C16H21NO2
CAS Registry Number 525-66-6
SMILES CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Intestinal ischaemia24.04.08.001; 07.15.02.0010.000187%Not Available
Irritability19.04.02.013; 08.01.03.0110.004247%
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.0040.000160%Not Available
Kawasaki's disease24.12.02.004; 11.07.01.007; 10.02.02.0090.000053%Not Available
Ketoacidosis14.01.01.0080.000214%Not Available
Lacrimation increased06.08.02.0040.000144%
Laryngospasm22.04.02.002--
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.0080.001512%
Lip ulceration07.05.06.0120.000080%Not Available
Livedo reticularis24.03.04.003; 23.06.05.0010.000171%Not Available
Loss of consciousness17.02.04.0040.000561%Not Available
Lower respiratory tract infection22.07.01.002; 11.01.09.002--Not Available
Meningioma17.20.01.005; 16.30.01.0050.000053%Not Available
Mesenteric artery thrombosis24.01.08.003; 07.15.02.008--Not Available
Metabolic acidosis14.01.01.0030.000347%Not Available
Middle insomnia19.02.01.003; 17.15.03.0030.002778%Not Available
Migraine17.14.02.001; 24.03.05.0030.000422%Not Available
Miosis17.02.11.002; 06.05.03.0030.000053%Not Available
Mitral valve incompetence02.07.01.0020.000053%Not Available
Mood swings19.04.03.001--Not Available
Muscle rigidity17.05.02.005; 15.05.04.0010.000118%Not Available
Muscle twitching15.05.03.0050.000353%Not Available
Muscular weakness17.05.03.005; 15.05.06.001--
Mydriasis17.02.11.003; 06.05.03.0040.000438%Not Available
Myopathy15.05.05.001--Not Available
Myositis15.05.01.0010.000080%
Nasal congestion22.04.04.0010.001197%
Nasal septum ulceration22.04.03.0160.000053%Not Available
Nausea07.01.07.001--
Necrosis24.04.02.006; 08.03.03.0010.000080%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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