Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Propranolol
Drug ID BADD_D01867
Description Propranolol is a racemic mixture of 2 enantiomers where the S(-)-enantiomer has approximately 100 times the binding affinity for beta adrenergic receptors.[L6904] Propranolol is used to treat a number of conditions but most commonly is used for hypertension.[L6901,L6904,L6907] Propranolol was granted FDA approval on 13 November 1967.[L6904]
Indications and Usage For the prophylaxis of migraine.
Marketing Status Prescription; Discontinued
ATC Code C07AA05
DrugBank ID DB00571
KEGG ID D08443
MeSH ID D011433
PubChem ID 4946
TTD Drug ID D04JEE
NDC Product Code Not Available
Synonyms Propranolol | Propanolol | Inderal | Avlocardyl | AY-20694 | AY 20694 | AY20694 | Rexigen | Dexpropranolol | Dociton | Obsidan | Obzidan | Propranolol Hydrochloride | Hydrochloride, Propranolol | Anaprilin | Anapriline | Betadren
Chemical Information
Molecular Formula C16H21NO2
CAS Registry Number 525-66-6
SMILES CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCytochrome P450 2D6P10635T57392Not Available
BradycardiaCytochrome P450 3A4P08684T3784816634720; 7594046; 8245337; 16770596; 10825413; 7694600
BradycardiaCytochrome P450 3A4P08684T3784812864757; 15209687; 11999139
HypotensionCytochrome P450 3A4P08684T3784812864757; 15209687; 11999139
HypotensionCytochrome P450 3A4P08684T3784816634720; 7594046; 8245337; 16770596; 10825413; 7694600
Mitochondrial toxicityCa2+/Mg2+ ATPaseQ63080Not Available3157382; 6324685; 2996181; 7994564; 6713449; 10370869; 2938592; 12498738; 2630100; 6316993
Poisoning and toxicityCytochrome P450 1A1P04798Not Available15094323; 11906967; 15224175
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
Sudden cardiac deathSodium channel protein type 5 subunit alphaQ14524T397169927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily E member 1P15382Not Available9927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily H member 2Q12809T202519927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily KQT member 1P51787T495269927398; 10810773; 10082151; 10408028
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Electrocardiogram PR shortened13.14.05.0020.000253%Not Available
Electrocardiogram QRS complex prolonged13.14.05.0030.001013%Not Available
Electrocardiogram QT prolonged13.14.05.0040.000633%
Electrocardiogram ST segment elevation13.14.05.0250.000253%Not Available
Encephalopathy17.13.02.0010.000380%
Eosinophilia01.02.04.0010.000253%
Epilepsy17.12.03.0020.001013%Not Available
Erysipelas11.02.06.001; 23.09.01.0020.000253%Not Available
Erythema23.03.06.0010.001519%Not Available
Erythema multiforme23.03.01.003; 10.01.03.015--
Escherichia sepsis11.02.10.0020.000066%Not Available
Euphoric mood19.04.02.0060.001013%
Eye pain06.08.03.0020.000380%
Eye swelling06.08.03.0030.000253%Not Available
Faeces discoloured07.01.03.0020.000380%Not Available
Fasciitis15.03.03.0010.000380%Not Available
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Feeling cold08.01.09.0080.000253%Not Available
Feeling hot08.01.09.0090.000506%Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Frequent bowel movements07.02.04.0020.000253%Not Available
Gait disturbance17.02.05.016; 08.01.02.0020.001393%
Gamma-glutamyltransferase increased13.03.01.011--
Gastrooesophageal reflux disease07.02.02.0030.001393%
Gastroenteritis viral11.05.04.005; 07.19.03.0050.000760%Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal haemorrhage07.12.02.001; 24.07.02.009--Not Available
Gastrointestinal infection11.01.07.012; 07.19.02.0050.000253%Not Available
Gastrointestinal necrosis24.04.08.006; 07.15.01.0030.000132%
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