Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Propofol
Drug ID BADD_D01864
Description Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.
Indications and Usage Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.
Marketing Status Prescription; Discontinued
ATC Code N01AX10
DrugBank ID DB00818
KEGG ID D00549
MeSH ID D015742
PubChem ID 4943
TTD Drug ID D0A3HB
NDC Product Code 72572-612; 69135-0010; 52584-699; 0409-4699; 50090-4569; 0641-6194; 25021-608; 63323-269; 0069-0209; 0069-0234; 51504-0003; 58032-2019; 51662-1470; 14593-885; 51662-1471; 72572-583; 44657-0044; 70518-3256; 0591-2136; 72572-590; 0641-6195; 0641-6196; 72572-585; 72572-601; 51662-1293; 18124-027; 65219-427; 0069-0248; 65219-800; 23155-345; 72572-584; 0404-9943; 66064-1015; 52133-0023; 52584-098
Synonyms Propofol | 2,6-Diisopropylphenol | 2,6 Diisopropylphenol | 2,6-Bis(1-methylethyl)phenol | Disoprofol | Diprivan | Disoprivan | Fresofol | ICI-35,868 | ICI 35,868 | ICI35,868 | ICI-35868 | ICI 35868 | ICI35868 | Ivofol | Propofol Fresenius | Propofol MCT | Propofol Rovi | Propofol-Lipuro | Recofol | Aquafol | Propofol Abbott
Chemical Information
Molecular Formula C12H18O
CAS Registry Number 2078-54-8
SMILES CC(C)C1=C(C(=CC=C1)C(C)C)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gait disturbance08.01.02.002; 17.02.05.016--
Gastrointestinal disorder07.11.01.001--Not Available
Generalised tonic-clonic seizure17.12.01.0020.003153%Not Available
Haematemesis24.07.02.011; 07.12.02.0020.000788%Not Available
Haemoglobin13.01.05.018--Not Available
Haemolytic anaemia01.06.03.0020.000788%Not Available
Hallucination19.10.02.002--
Headache17.14.01.001--
Heart rate decreased13.14.04.0010.000788%Not Available
Heart rate increased13.14.04.0020.001182%Not Available
Hepatic congestion09.01.05.008; 02.05.04.0130.000411%Not Available
Hepatic failure09.01.03.0020.000206%
Hepatic function abnormal09.01.02.001--Not Available
Hepatitis09.01.07.0040.003153%Not Available
Hepatitis acute09.01.07.0050.001182%Not Available
Hepatitis C11.05.06.004; 09.01.09.0050.000788%Not Available
Hepatocellular injury09.01.07.0080.001970%Not Available
Hepatorenal failure20.01.03.013; 09.01.03.0080.004335%Not Available
Hepatorenal syndrome20.01.03.012; 09.01.03.0070.000206%Not Available
Hiccups22.02.04.002; 07.01.06.009--
Hypercapnia14.01.04.001; 22.02.02.0020.000308%Not Available
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hyperhidrosis08.01.03.028; 23.02.03.0040.003153%
Hyperkalaemia14.05.03.0010.004335%
Hyperlactacidaemia14.01.01.0060.001576%Not Available
Hyperphosphataemia14.04.03.0070.000788%
Hypersensitivity10.01.03.0030.006305%
Hypertension24.08.02.001--
Hypertensive crisis24.08.01.0010.001182%Not Available
Hyperthermia malignant08.05.01.0020.002364%Not Available
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