Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Propantheline
Drug ID BADD_D01860
Description A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking.
Indications and Usage For the treatment of enuresis. It has also been used for hyperhidrosis, and cramps or spasms of the stomach, intestines or bladder.
Marketing Status Prescription; Discontinued
ATC Code A03AB05
DrugBank ID DB00782
KEGG ID C07506
MeSH ID D011413
PubChem ID 4934
TTD Drug ID D0V5ZZ
NDC Product Code Not Available
Synonyms Propantheline | Propantheline Bromide | Bromide, Propantheline | Probanthine | Pro-Banthine | Pro Banthine
Chemical Information
Molecular Formula C23H30NO3+
CAS Registry Number 298-50-0
SMILES CC(C)[N+](C)(CCOC(=O)C1C2=CC=CC=C2OC3=CC=CC=C13)C(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Accommodation disorder06.02.04.001--Not Available
Anaphylactic shock10.01.07.002; 24.06.02.004--Not Available
Anhidrosis23.02.03.001--Not Available
Asthenia08.01.01.001--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Cycloplegia17.17.02.003; 06.05.03.002--Not Available
Dermatitis23.03.04.002--Not Available
Dermatitis atopic23.03.04.016; 10.01.04.004--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry mouth07.06.01.002--
Dysphagia07.01.06.003--
Feeling abnormal08.01.09.014--Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Headache17.14.01.001--
Heat stroke24.06.02.009; 12.05.01.001--Not Available
Hypersensitivity10.01.03.003--
Hypohidrosis23.02.03.005; 08.01.03.029--
Insomnia17.15.03.002; 19.02.01.002--
Mydriasis17.02.11.003; 06.05.03.004--Not Available
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Palpitations02.01.02.003--
Rash23.03.13.001--Not Available
Salivary hypersecretion07.06.01.009--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Tachycardia02.03.02.007--Not Available
Tension19.06.02.005--Not Available
Thirst14.03.02.007; 08.01.09.021--Not Available
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