Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Propafenone hydrochloride
Drug ID BADD_D01857
Description An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated.
Indications and Usage Used to prolong the time to recurrence of paroxysmal atrial fibrillation/flutter (PAF) associated with disabling symptoms in patients without structural heart disease. Also used for the treatment of life-threatening documented ventricular arrhythmias, such as sustained ventricular tachycardia.
Marketing Status Prescription; Discontinued
ATC Code C01BC03
DrugBank ID DB01182
KEGG ID D00640
MeSH ID D011405
PubChem ID 36708
TTD Drug ID D0J2KV
NDC Product Code 0591-2286; 49884-210; 42291-545; 50090-1134; 63629-2105; 63629-2268; 42291-546; 68382-524; 53489-552; 63629-1988; 63629-2265; 60687-537; 70771-1525; 0591-2287; 50090-4227; 0591-0582; 50090-2975; 12598-6278; 12598-6220; 16714-827; 49706-0201; 68382-522; 68382-523; 16714-825; 66993-115; 0603-5450; 0591-0583; 68084-917; 59651-256; 65015-671; 64380-185; 64380-184; 0603-5448; 63629-2267; 62559-230; 0591-2285; 70771-1527; 70771-1526; 0603-5449; 62559-232; 42291-547; 51407-016; 68462-409; 53489-551; 63629-1989; 16571-736; 59651-258; 16571-738; 68108-0340; 0832-0741; 0173-0826; 0832-0740; 51407-017; 0832-0742; 60429-976; 12598-6218; 46016-0320; 16571-737; 63629-2271; 63629-2269; 63629-2272; 12780-4900; 60429-438; 64380-186; 63629-2273; 59651-257; 68462-410; 0173-0824; 49884-211; 65841-170; 66993-114; 53489-553; 62559-231; 60429-437; 12598-6283; 68462-408; 60687-185; 16714-826; 63629-2270; 0173-0823; 12598-6216; 63629-2266; 12598-6280; 49884-113
Synonyms Propafenone | Propafenone Hydrochloride, (R)-Isomer | Rytmo-Puren | Rytmogenat | SA-79 | SA 79 | SA79 | Propafenone, (+-)-Isomer | Propafenone, (R)-Isomer | Propafenone, (S)-Isomer | Propamerck | Apo-Propafenone | Baxarytmon | Cuxafenon | Fenoprain | Jutanorm | Nistaken | Prolecofen | Propafenon AL | Propafenon Hexal | Propafenone Hydrochloride | Hydrochloride, Propafenone | Propafenone Hydrochloride, (S)-Isomer | Rythmol | Propafenon Minden | Norfenon | Pintoform | Rytmonorm | Arythmol
Chemical Information
Molecular Formula C21H28ClNO3
CAS Registry Number 34183-22-7
SMILES CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
Sudden cardiac deathPotassium voltage-gated channel subfamily E member 1P15382Not AvailableNot Available
Sudden cardiac deathPotassium voltage-gated channel subfamily H member 2Q12809T20251Not Available
Sudden cardiac deathPotassium voltage-gated channel subfamily KQT member 1P51787T49526Not Available
Sudden cardiac deathSodium channel protein type 5 subunit alphaQ14524T39716Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dysgeusia17.02.07.003; 07.14.03.001--
Dyspepsia07.01.02.001--
Dyspnoea22.02.01.004; 02.01.03.002--
Eye irritation06.04.05.003--Not Available
Fatigue08.01.01.002--
Flatulence07.01.04.002--
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Gastroenteritis11.01.07.004; 07.19.03.001--Not Available
Granulocytopenia01.02.03.003--Not Available
Headache17.14.01.001--
Hepatitis09.01.07.004--Not Available
Hypoaesthesia17.02.06.023--Not Available
Hyponatraemia14.05.04.002--
Leukopenia01.02.02.001--Not Available
Mania19.16.02.002--
Muscle spasms15.05.03.004--
Muscular weakness17.05.03.005; 15.05.06.001--
Nausea07.01.07.001--
Nephrotic syndrome20.05.01.002--
Oesophagitis07.08.05.001--
Pain08.01.08.004--
Palpitations02.01.02.003--
Paraesthesia17.02.06.005--
Parosmia22.04.03.007; 17.04.04.002--Not Available
Pruritus23.03.12.001--
Purpura24.07.06.005; 23.06.01.004; 01.01.04.003--
Pyrexia08.05.02.003--
Renal failure20.01.03.005--Not Available
Seizure17.12.03.001--
Sinus arrest02.03.03.007--Not Available
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