Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Propafenone
Drug ID BADD_D01856
Description An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated.
Indications and Usage Used to prolong the time to recurrence of paroxysmal atrial fibrillation/flutter (PAF) associated with disabling symptoms in patients without structural heart disease. Also used for the treatment of life-threatening documented ventricular arrhythmias, such as sustained ventricular tachycardia.
Marketing Status Prescription; Discontinued
ATC Code C01BC03
DrugBank ID DB01182
KEGG ID D08435
MeSH ID D011405
PubChem ID 4932
TTD Drug ID D0J2KV
NDC Product Code 51407-477; 51407-479; 24979-087; 71205-940; 12598-6285; 51407-478; 24979-085; 69680-130; 71205-941; 69680-132; 69680-131; 71205-942; 24979-086
Synonyms Propafenone | Propafenone Hydrochloride, (R)-Isomer | Rytmo-Puren | Rytmogenat | SA-79 | SA 79 | SA79 | Propafenone, (+-)-Isomer | Propafenone, (R)-Isomer | Propafenone, (S)-Isomer | Propamerck | Apo-Propafenone | Baxarytmon | Cuxafenon | Fenoprain | Jutanorm | Nistaken | Prolecofen | Propafenon AL | Propafenon Hexal | Propafenone Hydrochloride | Hydrochloride, Propafenone | Propafenone Hydrochloride, (S)-Isomer | Rythmol | Propafenon Minden | Norfenon | Pintoform | Rytmonorm | Arythmol
Chemical Information
Molecular Formula C21H27NO3
CAS Registry Number 54063-53-5
SMILES CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
Sudden cardiac deathPotassium voltage-gated channel subfamily KQT member 1P51787T495269927398; 10810773; 10082151; 10408028
Sudden cardiac deathSodium channel protein type 5 subunit alphaQ14524T397169927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily E member 1P15382Not Available9927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily H member 2Q12809T202519927398; 10810773; 10082151; 10408028
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Flatulence07.01.04.002--
Flushing23.06.05.003; 08.01.03.025; 24.03.01.002--
Food interaction08.06.03.0020.002874%Not Available
Gait disturbance17.02.05.016; 08.01.02.002--
Gamma-glutamyltransferase increased13.03.01.011--
Gastritis07.08.02.001--
Gastrooesophageal reflux disease07.02.02.003--
Gastroenteritis11.01.07.004; 07.19.03.001--Not Available
Gastrointestinal disorder07.11.01.0010.001916%Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.0010.001916%Not Available
Gastrointestinal pain07.01.05.005--
Generalised tonic-clonic seizure17.12.01.0020.012453%Not Available
Gingival bleeding24.07.02.010; 07.09.07.001--Not Available
Gingival pain07.09.04.001--
Glossitis07.14.01.001--Not Available
Glossodynia07.14.02.001--Not Available
Glycosuria20.02.01.005--
Gout14.09.01.001; 15.01.06.001--Not Available
Haematoma24.07.01.001--
Haematuria24.07.01.047; 20.02.01.0060.003832%
Haemoglobin13.01.05.018--Not Available
Haemoglobin decreased13.01.05.003--Not Available
Haemolysis01.06.04.0020.001916%
Haemoptysis22.02.03.004; 02.01.02.006; 24.07.01.006--Not Available
Headache17.14.01.001--
Heart rate irregular13.14.04.0030.006705%Not Available
Heart sounds abnormal13.14.01.002--Not Available
Hepatic function abnormal09.01.02.001--Not Available
Hepatic steatosis14.08.04.005; 09.01.07.0030.001916%Not Available
Hepatitis09.01.07.004--Not Available
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