Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Promethazine
Drug ID BADD_D01854
Description Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946.[A189901] Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A190153,A190159,A190150,A190171] Promethazine was granted FDA approval before 29 March 1951.[A190177,L4000]
Indications and Usage For the treatment of allergic disorders, and nausea/vomiting.
Marketing Status Prescription; Discontinued
ATC Code D04AA10; R06AD02
DrugBank ID DB01069
KEGG ID D00494
MeSH ID D011398
PubChem ID 4927
TTD Drug ID D0T2XU
NDC Product Code 65162-678; 54348-117
Synonyms Promethazine | Prometazin | Proazamine | Rumergan | Diprazin | Isopromethazine | Phenergan | Phenargan | Phensedyl | Pipolfen | Pipolphen | Promet | Promethazine Hydrochloride | Hydrochloride, Promethazine | Prothazin | Pyrethia | Remsed | Atosil | Diphergan
Chemical Information
Molecular Formula C17H20N2S
CAS Registry Number 60-87-7
SMILES CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.0010.002785%
Abdominal pain07.01.05.002--
Abortion spontaneous18.01.04.0010.002785%Not Available
Abscess11.01.08.0010.004177%Not Available
Aggression19.05.01.0010.008354%Not Available
Agitation19.06.02.001; 17.02.05.0120.023669%
Agranulocytosis01.02.03.001--Not Available
Akathisia19.06.02.006; 17.01.02.0020.009746%
Amnesia17.03.02.001; 19.20.01.0010.004177%
Anaphylactic reaction24.06.03.006; 10.01.07.0010.015315%
Anaphylactic shock10.01.07.002; 24.06.02.004--Not Available
Angioedema23.04.01.001; 10.01.05.0090.004177%Not Available
Anticholinergic syndrome17.05.01.0010.008354%Not Available
Anxiety19.06.02.0020.034808%
Aphasia19.21.01.001; 17.02.03.0010.006962%
Aplastic anaemia01.03.03.002--Not Available
Apnoea22.02.01.0010.000726%
Arrhythmia02.03.02.001--Not Available
Arthralgia15.01.02.001--
Asthenia08.01.01.0010.011138%Not Available
Asthma22.03.01.002; 10.01.03.010--Not Available
Ataxia08.01.02.004; 17.02.02.0010.008354%
Back pain15.03.04.0050.005569%
Blister23.03.01.001; 12.01.06.0020.004177%Not Available
Blood creatine phosphokinase increased13.04.01.0010.006962%
Blood pressure decreased13.14.03.0020.002785%Not Available
Blood pressure increased13.14.03.005--Not Available
Bradycardia02.03.02.002--Not Available
Burning sensation17.02.06.001; 08.01.09.0290.002785%Not Available
Cardiac arrest02.03.04.0010.002179%
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