Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Probenecid
Drug ID BADD_D01841
Description The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
Indications and Usage For the reduction of serum uric acid concentrations in chronic gouty arthritis and tophaceous gout in patients with frequent disabling gout attacks. Has also been effectively used to promote uric acid excretion in hyperuricemia secondary to the administration of thiazide and related diuretics.
Marketing Status Prescription; Discontinued
ATC Code M04AB01
DrugBank ID DB01032
KEGG ID D00475
MeSH ID D011339
PubChem ID 4911
TTD Drug ID D0L7FM
NDC Product Code 10135-541; 63629-8213; 0591-5347; 71626-999; 0527-1367; 68022-7061; 71335-1697; 57451-1120; 43235-0015; 63415-0026
Synonyms Probenecid | Probenecid Weimer | Pro-Cid | Probecid | Benuryl | Benecid | Benemid
Chemical Information
Molecular Formula C13H19NO4S
CAS Registry Number 57-66-9
SMILES CCCN(CCC)S(=O)(=O)C1=CC=C(C=C1)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Alopecia23.02.02.001--
Anaemia01.03.02.001--
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Aplastic anaemia01.03.03.002--Not Available
Body temperature increased13.15.01.001--Not Available
Calculus urinary20.04.02.001--Not Available
Dermatitis23.03.04.002--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Erythema multiforme23.03.01.003; 10.01.03.015--
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Gingival pain07.09.04.001--
Gouty arthritis15.01.06.004; 14.09.01.004--Not Available
Haematuria24.07.01.047; 20.02.01.006--
Haemolytic anaemia01.06.03.002--Not Available
Headache17.14.01.001--
Hepatic necrosis09.01.07.002--
Hypersensitivity10.01.03.003--
Leukopenia01.02.02.001--Not Available
Nausea07.01.07.001--
Nephrotic syndrome20.05.01.002--
Pain08.01.08.004--
Pollakiuria20.02.02.007--
Pruritus23.03.12.001--
Pyrexia08.05.02.003--
Renal colic20.02.03.010--
Stevens-Johnson syndrome23.03.01.007; 12.03.01.014; 11.07.01.005; 10.01.03.020--
Toxic epidermal necrolysis11.07.01.006; 10.01.01.006; 23.03.01.008; 12.03.01.015--
Urticaria23.04.02.001; 10.01.06.001--
Vomiting07.01.07.003--
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