Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pralatrexate
Drug ID BADD_D01814
Description Pralatrexate is an antimetabolite for the treatment of relapsed or refractory peripheral T-cell lymphoma. It is more efficiently retained in cancer cells than methotrexate. FDA approved on September 24, 2009.
Indications and Usage Treatment of relapsed or refractory peripheral T-cell lymphoma.
Marketing Status Prescription
ATC Code L01BA05
DrugBank ID DB06813
KEGG ID D05589
MeSH ID C418863
PubChem ID 148121
TTD Drug ID D02LWU
NDC Product Code 72893-003; 48818-001; 47848-045; 68554-0071; 53183-4020; 72893-005; 65392-2510
Synonyms 10-propargyl-10-deazaaminopterin | pralatrexate
Chemical Information
Molecular Formula C23H23N7O5
CAS Registry Number 146464-95-1
SMILES C#CCC(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.0020.000799%
Acute myeloid leukaemia16.01.05.001; 01.10.05.0010.000139%Not Available
Anaemia01.03.02.0010.001598%
Asthenia08.01.01.001--Not Available
Back pain15.03.04.005--
Blood lactate dehydrogenase increased13.04.02.0020.000533%
Body temperature increased13.15.01.001--Not Available
Cardio-respiratory arrest22.02.06.007; 02.03.04.002--Not Available
Constipation07.02.02.001--
Cough22.02.03.001--
Death08.04.01.001--
Dehydration14.05.05.001--
Dermatitis23.03.04.002--Not Available
Dermatitis bullous23.03.01.0020.000533%
Diarrhoea07.02.01.001--
Dyspnoea22.02.01.004; 02.01.03.002--
Epistaxis24.07.01.005; 22.04.03.001--
Erythema multiforme23.03.01.003; 10.01.03.0150.000533%
Fatigue08.01.01.002--
Febrile neutropenia08.05.02.004; 01.02.03.0020.000139%
Gastrointestinal pain07.01.05.005--
Haematemesis24.07.02.011; 07.12.02.0020.000533%Not Available
Hypokalaemia14.05.03.002--
Interstitial lung disease22.01.02.003; 10.02.01.0330.001066%Not Available
Laryngeal pain22.02.05.036--
Leukopenia01.02.02.001--Not Available
Liver disorder09.01.08.0010.000533%Not Available
Liver function test abnormal13.03.01.013--Not Available
Lymphopenia01.02.02.0020.000533%Not Available
Mucosal inflammation08.01.06.0020.001865%Not Available
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