Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Piroxicam
Drug ID BADD_D01784
Description A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily.
Indications and Usage For treatment of osteoarthritis and rheumatoid arthritis.
Marketing Status Prescription; Discontinued
ATC Code M01AC01; M02AA07; S01BC06
DrugBank ID DB00554
KEGG ID D00127
MeSH ID D010894
PubChem ID 54676228
TTD Drug ID D00IBN
NDC Product Code 22365-114; 59762-0145; 53747-044; 72789-210; 0395-8163; 0143-3107; 0069-3220; 59762-0140; 59348-0014; 46438-0053; 68981-041; 71205-032; 0069-3230; 60592-604; 17337-0538; 60715-3270; 29300-255; 0143-3108; 61919-193; 29300-256; 51927-0145; 29033-012; 46438-0639; 64380-842; 38779-0302; 0093-0756; 42543-115; 72789-211; 42571-176; 42571-177; 49452-5476; 42291-677; 70771-1430; 42291-674; 29033-013; 50090-4779; 51927-1699; 70771-1429; 0093-0757; 63629-9150; 62991-1113; 55700-697; 64380-843; 71335-1999; 63629-9148; 63629-9149; 71205-203; 42543-114; 61919-188; 63187-972
Synonyms Piroxicam | CP-16171 | CP 16171 | CP16171 | Feldene
Chemical Information
Molecular Formula C15H13N3O4S
CAS Registry Number 36322-90-4
SMILES CN1C(=C(C2=CC=CC=C2S1(=O)=O)O)C(=O)NC3=CC=CC=N3
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Hepatic function abnormalGlycogen [starch] synthase, muscleP13807Not Available1338186; 7733654; 6416813; 6766890; 237970; 7575414; 3105560; 6096366
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Ill-defined disorder08.01.03.049--Not Available
Abnormal sleep-related event19.02.03.009; 17.15.02.0070.004300%Not Available
Pulmonary function test decreased13.19.01.001--Not Available
Renal impairment20.01.03.010--Not Available
Cystitis noninfective20.03.02.001--
Oral mucosa erosion07.05.06.0090.004300%Not Available
Drug-induced liver injury09.01.07.023; 12.03.01.0440.006450%Not Available
Drug reaction with eosinophilia and systemic symptoms23.03.05.005; 10.01.01.0210.008600%Not Available
Perforation08.01.03.058--Not Available
Ductus arteriosus stenosis foetal24.03.03.027; 03.07.09.0060.004300%Not Available
Penile ulceration23.07.03.020; 21.12.01.0190.004300%Not Available
Spinal column stenosis17.10.01.011; 15.10.04.0030.004300%Not Available
Spinal cord infection17.06.02.004; 11.01.03.0130.001683%Not Available
Lip erosion07.05.01.0160.004300%Not Available
Embolia cutis medicamentosa08.02.03.052; 24.01.01.030; 12.07.03.0520.004300%Not Available
Erosive duodenitis07.04.02.0060.004300%Not Available
Hyperlipasaemia14.11.01.0230.006450%Not Available
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