Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Piroxicam
Drug ID BADD_D01784
Description A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily.
Indications and Usage For treatment of osteoarthritis and rheumatoid arthritis.
Marketing Status Prescription; Discontinued
ATC Code M01AC01; M02AA07; S01BC06
DrugBank ID DB00554
KEGG ID D00127
MeSH ID D010894
PubChem ID 54676228
TTD Drug ID D00IBN
NDC Product Code 22365-114; 59762-0145; 53747-044; 72789-210; 0395-8163; 0143-3107; 0069-3220; 59762-0140; 59348-0014; 46438-0053; 68981-041; 71205-032; 0069-3230; 60592-604; 17337-0538; 60715-3270; 29300-255; 0143-3108; 61919-193; 29300-256; 51927-0145; 29033-012; 46438-0639; 64380-842; 38779-0302; 0093-0756; 42543-115; 72789-211; 42571-176; 42571-177; 49452-5476; 42291-677; 70771-1430; 42291-674; 29033-013; 50090-4779; 51927-1699; 70771-1429; 0093-0757; 63629-9150; 62991-1113; 55700-697; 64380-843; 71335-1999; 63629-9148; 63629-9149; 71205-203; 42543-114; 61919-188; 63187-972
Synonyms Piroxicam | CP-16171 | CP 16171 | CP16171 | Feldene
Chemical Information
Molecular Formula C15H13N3O4S
CAS Registry Number 36322-90-4
SMILES CN1C(=C(C2=CC=CC=C2S1(=O)=O)O)C(=O)NC3=CC=CC=N3
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Hepatic function abnormalGlycogen [starch] synthase, muscleP13807Not Available1338186; 7733654; 6416813; 6766890; 237970; 7575414; 3105560; 6096366
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Meningitis17.06.03.001; 11.01.03.001--
Meningitis aseptic17.06.03.002; 11.01.03.002--Not Available
Menorrhagia21.01.03.002--
Mood altered19.04.02.007--Not Available
Muscle spasms15.05.03.0040.004300%
Myocardial infarction24.04.04.009; 02.02.02.007--
Nausea07.01.07.001--
Nephropathy20.05.03.0010.004300%Not Available
Nephropathy toxic20.05.03.002; 12.03.01.0100.004300%Not Available
Nephrotic syndrome20.05.01.002--
Nervousness19.06.02.003--Not Available
Oedema14.05.06.010; 08.01.07.0060.008600%Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.0070.008600%
Oesophagitis07.08.05.001--
Oliguria20.01.03.0040.006450%Not Available
Onycholysis23.02.05.004--Not Available
Pain08.01.08.004--
Pallor23.03.03.031; 08.01.03.032; 24.03.04.0010.004300%Not Available
Palpitations02.01.02.003--
Pancreatitis07.18.01.001--
Pancytopenia01.03.03.0030.004300%Not Available
Paraesthesia17.02.06.0050.004300%
Paraplegia17.01.04.0070.004300%Not Available
Peptic ulcer07.04.07.001--Not Available
Personality change19.05.01.006; 17.02.05.019--
Petechiae01.01.03.002; 24.07.06.004; 23.06.01.003--Not Available
Photosensitivity reaction23.03.09.003--
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Pollakiuria20.02.02.007--
Polyneuropathy17.09.03.0120.008600%Not Available
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