Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pirfenidone
Drug ID BADD_D01783
Description Pirfenidone is an orally active small molecule drug that may inhibit collagen synthesis, down regulate production of multiple cytokines and block fibroblast proliferation and stimulation in response to cytokines. Pirfenidone has demonstrated activity in multiple fibrotic conditions, including those of the lung, kidney and liver. It is being investigated by InterMune.
Indications and Usage For the treatment of idiopathic pulmonary fibrosis (IPF).
Marketing Status Prescription; Discontinued
ATC Code L04AX05
DrugBank ID DB04951
KEGG ID D01583
MeSH ID C093844
PubChem ID 40632
TTD Drug ID D02WCI
NDC Product Code 65372-1197; 46708-907; 73309-052; 46016-5310; 62207-004; 62512-0070; 69037-0013; 53104-7712; 11014-0214; 59285-013; 76072-1006; 69766-030; 50242-122; 57297-140; 46016-5312; 46438-0648; 60219-1642; 50242-121; 50242-123; 59651-199; 60219-1640; 60219-1641; 60862-005; 42571-329; 63759-7005
Synonyms pirfenidone | 5-methyl-1-phenyl-2-(1H)-pyridone | Esbriet | deupirfenidone | 1-phenyl-5-(trideuteriomethyl)-1,2-dihydropyridin-2-one | Deskar
Chemical Information
Molecular Formula C12H11NO
CAS Registry Number 53179-13-8
SMILES CC1=CN(C(=O)C=C1)C2=CC=CC=C2
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Flank pain08.01.08.007; 20.02.03.006; 15.03.04.0030.001158%
Flatulence07.01.04.0020.006369%
Fluid retention20.01.02.003; 14.05.06.002--Not Available
Flushing24.03.01.002; 08.01.03.025; 23.06.05.003--
Fracture12.04.02.001; 15.08.02.001--
Frequent bowel movements07.02.04.0020.005211%Not Available
Fungal infection11.03.05.001--Not Available
Gait disturbance17.02.05.016; 08.01.02.002--
Gamma-glutamyltransferase increased13.03.01.0110.004053%
Gastric ulcer07.04.03.002--
Gastritis07.08.02.0010.005211%
Gastrooesophageal reflux disease07.02.02.0030.023160%
Gastroenteritis07.19.03.001; 11.01.07.004--Not Available
Gastroenteritis viral11.05.04.005; 07.19.03.0050.002895%Not Available
Gastrointestinal disorder07.11.01.0010.039371%Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Gastrointestinal pain07.01.05.0050.005211%
Gout15.01.06.001; 14.09.01.0010.001737%Not Available
Groin pain15.03.02.0040.001158%Not Available
Guillain-Barre syndrome17.09.01.001; 11.07.01.001; 10.04.10.0050.001158%
Haematemesis24.07.02.011; 07.12.02.002--Not Available
Haematoma24.07.01.001--
Blood urine present13.13.02.002--Not Available
Haemoglobin decreased13.01.05.003--Not Available
Haemoptysis02.01.02.006; 24.07.01.006; 22.02.03.0040.011001%Not Available
Hallucination19.10.02.002--
Head discomfort17.02.05.0270.001158%Not Available
Headache17.14.01.001--
Heart rate increased13.14.04.0020.008106%Not Available
Hepatic cirrhosis09.01.04.0010.000604%Not Available
The 6th Page    First    Pre   6 7 8 9 10    Next   Last    Total 18 Pages