Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pirfenidone
Drug ID BADD_D01783
Description Pirfenidone is an orally active small molecule drug that may inhibit collagen synthesis, down regulate production of multiple cytokines and block fibroblast proliferation and stimulation in response to cytokines. Pirfenidone has demonstrated activity in multiple fibrotic conditions, including those of the lung, kidney and liver. It is being investigated by InterMune.
Indications and Usage For the treatment of idiopathic pulmonary fibrosis (IPF).
Marketing Status Prescription; Discontinued
ATC Code L04AX05
DrugBank ID DB04951
KEGG ID D01583
MeSH ID C093844
PubChem ID 40632
TTD Drug ID D02WCI
NDC Product Code 65372-1197; 46708-907; 73309-052; 46016-5310; 62207-004; 62512-0070; 69037-0013; 53104-7712; 11014-0214; 59285-013; 76072-1006; 69766-030; 50242-122; 57297-140; 46016-5312; 46438-0648; 60219-1642; 50242-121; 50242-123; 59651-199; 60219-1640; 60219-1641; 60862-005; 42571-329; 63759-7005
Synonyms pirfenidone | 5-methyl-1-phenyl-2-(1H)-pyridone | Esbriet | deupirfenidone | 1-phenyl-5-(trideuteriomethyl)-1,2-dihydropyridin-2-one | Deskar
Chemical Information
Molecular Formula C12H11NO
CAS Registry Number 53179-13-8
SMILES CC1=CN(C(=O)C=C1)C2=CC=CC=C2
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Confusional state17.02.03.005; 19.13.01.001--
Constipation07.02.02.0010.022581%
Coronary artery disease24.04.04.006; 02.02.01.001--Not Available
Cough22.02.03.0010.052109%
Creatinine renal clearance increased13.13.01.0150.001158%Not Available
Crying17.02.05.013; 19.04.02.002; 12.02.11.001; 08.01.03.005--Not Available
Cystic fibrosis22.03.01.015; 07.18.03.001; 03.16.01.0020.000302%Not Available
Cystitis20.03.02.002; 11.01.14.0010.002316%
Deafness04.02.01.0010.002316%Not Available
Death08.04.01.0010.144244%
Dehydration14.05.05.001--
Delirium19.13.02.001--
Dementia19.20.02.001; 17.03.01.001--Not Available
Depressed mood19.15.02.0010.006369%Not Available
Depression19.15.01.001--
Dermatitis23.03.04.0020.004632%Not Available
Dermatitis allergic23.03.04.003; 10.01.03.0140.002895%Not Available
Dermatitis bullous23.03.01.0020.001737%
Dermatitis contact23.03.04.004; 12.03.01.040; 10.01.01.0030.001158%Not Available
Dermatitis exfoliative23.03.07.001; 10.01.01.0040.001737%
Diabetes mellitus14.06.01.001; 05.06.01.001--Not Available
Diarrhoea07.02.01.0010.107113%
Diarrhoea haemorrhagic24.07.02.004; 07.02.01.0020.001737%Not Available
Discomfort08.01.08.0030.004632%Not Available
Disorientation17.02.05.015; 19.13.01.002--Not Available
Disturbance in attention19.21.02.002; 17.03.03.001--
Diverticulitis11.01.07.003; 07.10.02.001--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.0040.075269%
Drug eruption23.03.05.001; 10.01.01.005; 08.01.06.015--Not Available
Drug hypersensitivity10.01.01.001--Not Available
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