Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pimozide
Drug ID BADD_D01774
Description A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994, p403)
Indications and Usage Used for the suppression of motor and phonic tics in patients with Tourette's Disorder who have failed to respond satisfactorily to standard treatment.
Marketing Status Prescription
ATC Code N05AG02
DrugBank ID DB01100
KEGG ID D00560
MeSH ID D010868
PubChem ID 16362
TTD Drug ID D00KHM
NDC Product Code 66577-017; 49884-347; 76438-002; 49884-348; 14474-029
Synonyms Pimozide | Antalon | Orap | Orap forte | R-6238 | R6238
Chemical Information
Molecular Formula C28H29F2N3O
CAS Registry Number 2062-78-4
SMILES C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCC(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Seizures (incl subtypes)G protein-activated inward rectifier potassium channel 1P48549T3801210780978; 12684268; 9504382; 15150531
Sinus tachycardiaG protein-activated inward rectifier potassium channel 1P48549T3801210780978; 12684268; 9504382; 15150531
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Endocrine disorder05.09.01.001--Not Available
Eosinophilia01.02.04.001--
Eructation07.01.02.003--
Extrapyramidal disorder17.01.02.007--
Eye disorder06.08.03.001--Not Available
Galactorrhoea21.05.02.002; 05.03.04.002--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Generalised tonic-clonic seizure17.12.01.002--Not Available
Gingival hyperplasia07.09.03.002--Not Available
Gynaecomastia21.05.04.003; 05.05.02.003--
Haemolytic anaemia01.06.03.002--Not Available
Headache17.14.01.001--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hyperkinesia17.01.02.008--Not Available
Hyperprolactinaemia05.03.01.002--Not Available
Hyperpyrexia08.05.02.002--Not Available
Hyperreflexia17.02.01.002--Not Available
Hypertension24.08.02.001--
Hyponatraemia14.05.04.002--
Hypotension24.06.03.002--
Hypothermia12.05.03.001; 08.05.01.003--
Increased appetite14.03.01.003; 08.01.09.027--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Leukopenia01.02.02.001--Not Available
Loss of consciousness17.02.04.004--Not Available
Loss of libido19.08.03.003--Not Available
Menstrual disorder21.01.01.004--Not Available
Muscle rigidity17.05.02.005; 15.05.04.001--Not Available
Muscle spasms15.05.03.004--
Myalgia15.05.02.001--
The 2th Page    First    Pre   2 3 4 5    Next   Last    Total 5 Pages