Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pimozide
Drug ID BADD_D01774
Description A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994, p403)
Indications and Usage Used for the suppression of motor and phonic tics in patients with Tourette's Disorder who have failed to respond satisfactorily to standard treatment.
Marketing Status Prescription
ATC Code N05AG02
DrugBank ID DB01100
KEGG ID D00560
MeSH ID D010868
PubChem ID 16362
TTD Drug ID D00KHM
NDC Product Code 66577-017; 49884-347; 76438-002; 49884-348; 14474-029
Synonyms Pimozide | Antalon | Orap | Orap forte | R-6238 | R6238
Chemical Information
Molecular Formula C28H29F2N3O
CAS Registry Number 2062-78-4
SMILES C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCC(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Seizures (incl subtypes)G protein-activated inward rectifier potassium channel 1P48549T3801210780978; 12684268; 9504382; 15150531
Sinus tachycardiaG protein-activated inward rectifier potassium channel 1P48549T3801210780978; 12684268; 9504382; 15150531
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abnormal dreams19.02.03.001; 17.15.02.001--Not Available
Accommodation disorder06.02.04.001--Not Available
Agitation19.06.02.001; 17.02.05.012--
Agranulocytosis01.02.03.001--Not Available
Akathisia19.06.02.006; 17.01.02.002--
Akinesia17.01.02.003--Not Available
Amenorrhoea21.01.02.001; 05.05.01.002--
Anaemia01.03.02.001--
Aplastic anaemia01.03.03.002--Not Available
Asthenia08.01.01.001--Not Available
Body temperature decreased13.15.01.010--Not Available
Bradykinesia17.01.02.004--Not Available
Breast discharge21.05.05.001--Not Available
Cataract06.06.01.001--
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Cogwheel rigidity15.05.04.006; 17.01.05.001--Not Available
Constipation07.02.02.001--
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Dizziness17.02.05.003; 24.06.02.007; 02.01.02.004--
Dry mouth07.06.01.002--
Dysgeusia07.14.03.001; 17.02.07.003--
Dyskinesia17.01.02.006--
Dysphagia07.01.06.003--
Dystonia17.01.03.001--Not Available
Electrocardiogram abnormal13.14.05.001--Not Available
Electrocardiogram QT prolonged13.14.05.004--
Electroencephalogram abnormal13.07.03.001--Not Available
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