Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pilocarpine hydrochloride
Drug ID BADD_D01771
Description A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
Indications and Usage For the treatment of radiation-induced dry mouth (xerostomia) and symptoms of dry mouth in patients with Sjögrens syndrome.
Marketing Status Discontinued; Prescription
ATC Code N07AX01; S01EB01
DrugBank ID DB01085
KEGG ID D02200
MeSH ID D010862
PubChem ID 5909
TTD Drug ID D06HLY
NDC Product Code 63629-2099; 17478-224; 0115-5911; 0074-7098; 0998-0204; 69205-001; 69238-1745; 69238-1746; 59212-775; 50384-0400; 59651-225; 38779-0182; 61314-204; 0527-1313; 17478-223; 51927-1528; 0228-2837; 0115-5922; 0998-0206; 16714-122; 61314-203; 50268-652; 0998-0203; 16714-121; 0228-2801; 63279-100; 17478-226; 0527-1407; 59651-224; 63629-8351; 12538-1921; 61314-206; 69238-1747; 68084-928; 59212-705
Synonyms Pilocarpine | Isoptocarpine | Salagen | Pilocarpine Hydrochloride | Hydrochloride, Pilocarpine | Pilocarpine, Monohydrochloride, (3S-cis)-Isomer | Pilocarpine Nitrate | Nitrate, Pilocarpine | Pilocarpine Mononitrate, (3S-cis)-Isomer | Isopilocarpine | Ocusert
Chemical Information
Molecular Formula C11H17ClN2O2
CAS Registry Number 54-71-7
SMILES CCC1C(COC1=O)CC2=CN=CN2C.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Seizures (incl subtypes)Mu-type opioid receptorP35372T47768Not Available
Seizures (incl subtypes)Delta-type opioid receptorP41143T58992Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Retinal detachment12.01.04.004; 06.09.03.003--
Retinal disorder06.08.03.005--Not Available
Rhinitis22.07.03.006; 11.01.13.004--
Salivary gland enlargement07.06.03.002--Not Available
Salivary hypersecretion07.06.01.009--Not Available
Salpingitis21.14.03.001; 11.01.10.001--Not Available
Seborrhoea23.02.07.001--Not Available
Seborrhoeic dermatitis23.03.04.018--Not Available
Shock24.06.02.002--Not Available
Sinusitis22.07.03.007; 11.01.13.005--
Skin odour abnormal23.03.03.012--
Skin ulcer24.04.03.007; 23.07.03.003--
Somnolence19.02.05.003; 17.02.04.006--
Speech disorder22.02.05.034; 19.19.02.002; 17.02.08.003--Not Available
Sputum increased22.02.03.007--Not Available
Stomatitis07.05.06.005--
Stridor22.04.02.003--
Syncope24.06.02.012; 17.02.04.008; 02.01.02.008--
Tachycardia02.03.02.007--Not Available
Tendon disorder15.07.01.002--Not Available
Tenosynovitis15.07.01.004--Not Available
Tension19.06.02.005--Not Available
Thinking abnormal19.10.03.001; 17.02.05.023--Not Available
Thrombocytopenia01.08.01.002--Not Available
Thrombocytosis01.08.02.001--Not Available
Thrombosis24.01.01.006--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Tongue disorder07.14.01.002--Not Available
Tooth disorder07.09.05.001--Not Available
Tremor17.01.06.002--
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