Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pilocarpine hydrochloride
Drug ID BADD_D01771
Description A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
Indications and Usage For the treatment of radiation-induced dry mouth (xerostomia) and symptoms of dry mouth in patients with Sjögrens syndrome.
Marketing Status Discontinued; Prescription
ATC Code N07AX01; S01EB01
DrugBank ID DB01085
KEGG ID D02200
MeSH ID D010862
PubChem ID 5909
TTD Drug ID D06HLY
NDC Product Code 63629-2099; 17478-224; 0115-5911; 0074-7098; 0998-0204; 69205-001; 69238-1745; 69238-1746; 59212-775; 50384-0400; 59651-225; 38779-0182; 61314-204; 0527-1313; 17478-223; 51927-1528; 0228-2837; 0115-5922; 0998-0206; 16714-122; 61314-203; 50268-652; 0998-0203; 16714-121; 0228-2801; 63279-100; 17478-226; 0527-1407; 59651-224; 63629-8351; 12538-1921; 61314-206; 69238-1747; 68084-928; 59212-705
Synonyms Pilocarpine | Isoptocarpine | Salagen | Pilocarpine Hydrochloride | Hydrochloride, Pilocarpine | Pilocarpine, Monohydrochloride, (3S-cis)-Isomer | Pilocarpine Nitrate | Nitrate, Pilocarpine | Pilocarpine Mononitrate, (3S-cis)-Isomer | Isopilocarpine | Ocusert
Chemical Information
Molecular Formula C11H17ClN2O2
CAS Registry Number 54-71-7
SMILES CCC1C(COC1=O)CC2=CN=CN2C.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Seizures (incl subtypes)Mu-type opioid receptorP35372T47768Not Available
Seizures (incl subtypes)Delta-type opioid receptorP41143T58992Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypoaesthesia17.02.06.023--Not Available
Hypoglycaemia14.06.03.001; 05.06.03.001--
Hypotension24.06.03.002--
Hypothermia12.05.03.001; 08.05.01.003--
Increased appetite14.03.01.003; 08.01.09.027--Not Available
Infection11.01.08.002--Not Available
Influenza22.07.02.001; 11.05.03.001--Not Available
Injury12.01.08.004--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Keratitis06.04.02.002--
Laboratory test abnormal13.18.01.001--Not Available
Lacrimation disorder06.08.02.010--Not Available
Lacrimation increased06.08.02.004--
Laryngitis22.07.03.001; 11.01.13.001--
Laryngospasm22.04.02.002--
Lenticular opacities06.06.01.003--Not Available
Leukopenia01.02.02.001--Not Available
Liver function test abnormal13.03.01.013--Not Available
Loss of consciousness17.02.04.004--Not Available
Lymphadenopathy01.09.01.002--Not Available
Mastitis21.05.03.002; 11.01.02.001--
Melaena24.07.02.013; 07.12.02.004--Not Available
Menorrhagia21.01.03.002--
Mental disability26.01.01.001--Not Available
Metrorrhagia21.01.01.006--Not Available
Micturition urgency20.02.02.006--
Migraine24.03.05.003; 17.14.02.001--Not Available
Mood swings19.04.03.001--Not Available
Mucous membrane disorder08.01.06.004--Not Available
Muscle spasms15.05.03.004--
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