| Pharmaceutical Information |
| Drug Name |
Phentermine |
| Drug ID |
BADD_D01756 |
| Description |
Phentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug.[A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine.[A174370] Phentermine has not been reported an addictive potential which allows this agent to be classified under the Schedule IV drugs (low abuse potential).[A174367]
Phentermine was FDA approved for short-term weight management in 1959 and it became widely used in 1960. This initial product, formed by the combination of phentermine with [fenfluramine] and [dexfenfluramine] was discontinued after finding several reports of abnormal valves in nearly 30% of the consumers.[A174376, T403] Later on, phentermine was approved alone and in combination with topiramate in 2012 as a new alternative that required lower doses of phentermine to obtain the desired effect.[A174373] |
| Indications and Usage |
For the treatment and management of obesity. |
| Marketing Status |
Prescription; Discontinued |
| ATC Code |
A08AA01 |
| DrugBank ID |
DB00191
|
| KEGG ID |
D05458
|
| MeSH ID |
D010645
|
| PubChem ID |
4771
|
| TTD Drug ID |
D0U0RZ
|
| NDC Product Code |
Not Available |
| Synonyms |
Phentermine | Duromine | Phentermine Hydrochloride | Hydrochloride, Phentermine | Adipex-P | Adipex P | AdipexP | Ionamine |
|
| Chemical Information |
| Molecular Formula |
C10H15N |
| CAS Registry Number |
122-09-8 |
| SMILES |
CC(C)(CC1=CC=CC=C1)N |
| Chemical Structure |
|
|
| ADR Related Proteins Induced by Drug |
| ADR Term |
Protein Name |
UniProt AC |
TTD Target ID |
PMID |
| Not Available | Not Available | Not Available | Not Available | Not Available |
|
| ADRs Induced by Drug |
|
|
