Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Encephalomalacia
ADR ID BADD_A08066
ADR Hierarchy
17      Nervous system disorders
17.11      Structural brain disorders
17.11.01      Structural brain disorders NEC
17.11.01.016      Encephalomalacia
Description Softening or loss of brain tissue following CEREBRAL INFARCTION; cerebral ischemia (see BRAIN ISCHEMIA), infection, CRANIOCEREBRAL TRAUMA, or other injury. The term is often used during gross pathologic inspection to describe blurred cortical margins and decreased consistency of brain tissue following infarction. Multicystic encephalomalacia refers to the formation of multiple cystic cavities of various sizes in the cerebral cortex of neonates and infants following injury, most notably perinatal hypoxia-ischemic events. (From Davis et al., Textbook of Neuropathology, 2nd ed, p665; J Neuropathol Exp Neurol, 1995 Mar;54(2):268-75) [MeSH]
MedDRA Code 10051818
MeSH ID D004678
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Encephalomalacia | Cerebral softening | Encephalomalacias | Cerebromalacia | Cerebromalacias | Multicystic Encephalomalacia | Encephalomalacias, Multicystic | Multicystic Encephalomalacias | Encephalomalacia, Multicystic
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Not AvailableNot AvailableNot Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00564Dabigatran etexilate0.001055%
BADD_D00706Donepezil0.000327%
BADD_D01265Levetiracetam0.000381%
BADD_D01756Phentermine0.001728%
BADD_D02105Tacrolimus0.001419%
BADD_D02150Temozolomide0.001332%
BADD_D02373Warfarin0.000420%
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