Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Phenobarbital
Drug ID BADD_D01752
Description A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
Indications and Usage For the treatment of all types of seizures except absence seizures.
Marketing Status Not Available
ATC Code N03AA02
DrugBank ID DB01174
KEGG ID D00506
MeSH ID D010634
PubChem ID 4763
TTD Drug ID D0Y7RW
NDC Product Code 58118-0626; 16571-673; 69336-115; 75826-136; 71205-889; 0143-1495; 17856-0502; 66064-2001; 63629-2404; 16571-668; 63629-2289; 70752-167; 0603-5166; 70518-0822; 69367-212; 76003-0894; 16571-669; 51927-1015; 67296-1427; 0603-5165; 70518-2612; 51293-626; 16571-674; 69367-214; 63629-2043; 70752-162; 63629-2049; 63739-294; 58118-1110; 16571-675; 69367-213; 64380-166; 71205-892; 70752-168; 63739-192; 13517-111; 63629-2045; 70752-161; 65319-1450; 0143-1458; 0603-5167; 63629-2044; 13517-110; 51293-627; 63629-2402; 51293-693; 75826-143; 38779-0852; 51293-694; 63187-895; 63629-2047; 51293-692; 43063-953; 70752-165; 70518-0722; 70752-164; 70752-166; 17856-0174; 63629-2046; 51293-625; 69367-211; 70518-2418; 63629-2401; 71205-891; 59348-0011; 63629-2041; 13517-758; 70166-536; 71205-890; 13517-756; 69336-116; 60687-448; 69336-117; 13517-113; 13517-112; 0121-0531; 63629-2400; 0143-1455; 63629-2403; 70518-2407; 58624-0520; 70166-537; 16571-667; 0603-5168; 75826-142; 0904-6575; 63629-2291; 61919-109; 75826-141; 70752-163; 63629-2399; 63629-2042; 70518-2405; 13517-755; 16571-671; 63629-2290; 0143-1500; 75826-139; 75826-138; 69367-172; 51552-0745; 16571-672; 13517-757; 51293-691; 16571-670; 63629-2048; 63629-1033; 13517-107; 69336-118; 51293-628; 49452-5190; 0395-8090; 71205-893; 54932-207; 75826-137; 0603-1508; 54932-501; 63629-1032; 75826-140; 70752-157
Synonyms Phenobarbital | Phenylbarbital | Phenylethylbarbituric Acid | Acid, Phenylethylbarbituric | Phenemal | Phenobarbitone | Hysteps | Phenobarbital Sodium | Sodium, Phenobarbital | Phenobarbital, Monosodium Salt | Monosodium Salt Phenobarbital | Luminal | Gardenal
Chemical Information
Molecular Formula C12H12N2O3
CAS Registry Number 50-06-6
SMILES CCC1(C(=O)NC(=O)NC1=O)C2=CC=CC=C2
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Toxicity to various agentsCytochrome P450 3A4P08684T37848Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Unresponsive to stimuli17.02.05.0310.000389%Not Available
Urinary hesitation20.02.02.009--Not Available
Urinary retention20.02.02.011--
Urticaria23.04.02.001; 10.01.06.001--
Vertigo17.02.12.002; 04.04.01.003--
Vision blurred17.17.01.010; 06.02.06.007--
Visual impairment06.02.06.0080.001490%Not Available
Vitamin K deficiency14.12.03.005--Not Available
Vomiting07.01.07.003--
Wheezing22.03.01.0090.001490%
Localised oedema14.05.06.009; 08.01.07.011; 02.05.04.006--
Brain oedema12.01.10.010; 17.07.02.0030.000389%
Musculoskeletal discomfort15.03.04.001--Not Available
Inappropriate antidiuretic hormone secretion05.03.03.001; 14.05.07.0010.001490%Not Available
Affect lability19.04.01.001--Not Available
Cognitive disorder19.21.02.001; 17.03.03.0030.002980%
Erectile dysfunction21.03.01.007; 19.08.04.001--
Pulmonary function test decreased13.19.01.001--Not Available
Suicidal behaviour19.12.01.006--Not Available
Foetal anticonvulsant syndrome18.03.03.001; 12.03.03.001; 03.02.02.0010.001490%Not Available
Liver injury12.01.02.003; 09.01.07.022--Not Available
Acute kidney injury20.01.03.0160.001490%
Drug-induced liver injury12.03.01.044; 09.01.07.0230.002235%Not Available
Drug reaction with eosinophilia and systemic symptoms10.01.01.021; 23.03.05.0050.017880%Not Available
Multiple organ dysfunction syndrome08.01.03.0570.000389%
Maternal drugs affecting foetus18.03.03.009; 12.03.03.0060.000389%Not Available
Anticonvulsant drug level below therapeutic13.17.01.0230.001490%Not Available
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